⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538791 | 0.59 | S100A4 (0.52) | — | |
| SCHEMBL4066187 | 0.58 | TDP1 (0.42) | — | |
| SCHEMBL7221349 | 0.57 | — | — | |
| SCHEMBL6575939 | 0.57 | PTPRC (0.59) | — | |
| SCHEMBL6607479 | 0.57 | MAOB (0.50) | — | |
| SCHEMBL5041817 | 0.57 | CTSL (0.53) | — | |
| SCHEMBL4438848 | 0.55 | — | — | |
| SCHEMBL2967094 | 0.55 | TDP2 (0.58) | — | |
| SCHEMBL1881159 | 0.54 | ALDH1A1 (0.33) | — | |
| SCHEMBL219949 | 0.53 | PKM (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113980001-B | Pyrazolol-pyridazinone coupling compound, pharmaceutical composition thereof and application of pyrazolol-pyridazinone coupling compound in medicines | 贵州医科大学 | 2024-01-30 | — | — | CN | claimed |
| US-20200253934-A1 | INHIBITORS OF PDE6DELTA FOR USE IN THE PREVENTION AND/OR TREATMENT OF EPILEPSY AND/OR NEURODEGENERATIVE DISORDERS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2020-08-13 | — | — | US | claimed |
| EP-3634407-A1 | INHIBITORS OF PDE6DELTA FOR USE IN THE PREVENTION AND/OR TREATMENT OF EPILEPSY AND/OR NEURODEGENERATIVE DISORDERS | Remynd N.V. (BE) | 2020-04-15 | — | — | EP | claimed |
| WO-2018206757-A1 | INHIBITORS OF PDE6DELTA FOR USE IN THE PREVENTION AND/OR TREATMENT OF EPILEPSY AND/OR NEURODEGENERATIVE DISORDERS | REMYND N.V. (BE) | 2018-11-15 | — | — | WO | claimed |
| WO-2006061428-A2 | GABA-A ALPHA 2 AND ALPHA 3 RECEPTOR AGONISTS FOR TREATING NEUROPATHIC, INFLAMMATORY AND MIGRAINE ASSOCIATED PAIN | Universität Zürich (CH) | 2006-06-15 | — | — | WO | claimed |
| CN-116157128-B | Pyrazolopyridazinone compounds, pharmaceutical compositions thereof and uses thereof | 北京伯汇生物技术有限公司 | 2025-08-05 | — | — | CN | disclosed |
| EP-4223759-B1 | PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | BROADENBIO CO LTD (CN) | 2025-06-11 | — | — | EP | disclosed |
| EP-4223759-B1 | PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | BROADENBIO CO LTD (CN) | 2025-06-11 | — | — | EP | disclosed |
| EP-4223759-C0 | PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | BROADENBIO CO LTD (CN) | 2025-06-11 | — | — | EP | disclosed |
| US-12178805-B2 | Inhibitors of PDE6Delta for use in the prevention and/or treatment of epilepsy and/or neurodegenerative disorders | REMYND N.V. (BE) | 2024-12-31 | — | — | US | disclosed |
| EP-4223759-A4 | PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Broadenbio Co., Ltd. (CN) | 2024-03-06 | — | — | EP | disclosed |
| CN-113980001-B | Pyrazolol-pyridazinone coupling compound, pharmaceutical composition thereof and application of pyrazolol-pyridazinone coupling compound in medicines | 贵州医科大学 | 2024-01-30 | — | — | CN | disclosed |
| US-6180630-B1 | USEFUL IN THE TREATMENT OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LIMITED (GB) | 2001-01-30 | — | — | US | disclosed |
| US-6180630-B1 | USEFUL IN THE TREATMENT OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LIMITED (GB) | 2001-01-30 | — | — | US | disclosed |
| WO-2000050034-A1 | GABA RECEPTORS MEDIATE INHIBITION OF T CELL RESPONSES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-2000039131-A1 | NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |
| EP-0991652-A1 | TRICYCLIC PYRAZOLO-PYRIDAZINONE ANALOGUES AS GABA-A RECEPTOR LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2000-04-12 | — | — | EP | disclosed |
| EP-0991652-A1 | TRICYCLIC PYRAZOLO-PYRIDAZINONE ANALOGUES AS GABA-A RECEPTOR LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000391-A1 | TRICYCLIC PYRAZOLO-PYRIDAZINONE ANALOGUES AS GABA-A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-01-07 | — | — | WO | disclosed |
| WO-1999000391-A1 | TRICYCLIC PYRAZOLO-PYRIDAZINONE ANALOGUES AS GABA-A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-01-07 | — | — | WO | disclosed |