Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14159972 | 0.81 | LMNA (0.48) | ALDH1A1CYP3A4MEN1KMT2ATSHR | |
| SCHEMBL6896287 | 0.79 | CYP3A4 (0.43) | ALDH1A1CYP3A4MEN1KMT2ATSHR | |
| SCHEMBL10179371 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ATSHRTDP1 | |
| SCHEMBL17067755 | 0.79 | TSHR (0.38) | ALDH1A1CYP3A4MEN1KMT2ATSHR | |
| SCHEMBL3298360 | 0.79 | TSHR (0.47) | ALDH1A1CYP3A4MEN1KMT2ATSHR | |
| SCHEMBL312407 | 0.79 | ALDH1A1 (0.50) | ALDH1A1CYP3A4MEN1KMT2ATSHR | |
| SCHEMBL2115890 | 0.77 | CA12 (0.49) | ALDH1A1GLACYP3A4NQO2MEN1 | |
| SCHEMBL18746334 | 0.76 | SMN1; SMN2 (0.51) | ALDH1A1MEN1KMT2ATSHRTDP1 | |
| SCHEMBL15712187 | 0.76 | MAPT (0.39) | ALDH1A1CYP3A4MEN1KMT2ATSHR | |
| SCHEMBL6787763 | 0.76 | XDH (0.49) | ALDH1A1MEN1KMT2ATSHRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250263399-A1 | CBL-B MODULATORS AND USES THEREOF | SCHRÖDINGER, INC. | 2025-08-21 | — | — | US | disclosed |
| EP-4568971-A1 | ANTAGONISTS OF 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPE 2B | Vanderbilt University (US) | 2025-06-18 | — | — | EP | disclosed |
| US-12325697-B2 | CBL-B modulators and uses thereof | NIMBUS CLIO, INC. (US) | 2025-06-10 | — | — | US | disclosed |
| US-12144816-B2 | Substituted indole Mcl-1 inhibitors | VANDERBILT UNIVERSITY (US) | 2024-11-19 | — | — | US | disclosed |
| US-20240150362-A1 | Substituted Pyrrolotriazines | MOLECURE S.A. (PL) | 2024-05-09 | — | — | US | disclosed |
| CN-117858707-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2024042494-A1 | SUBSTITUTED PYRROLOTRIAZINES | MOLECURE SA (PL) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024036183-A1 | ANTAGONISTS OF 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPE 2B | VANDERBILT UNIVERSITY (US) | 2024-02-15 | — | — | WO | disclosed |
| EP-4319756-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| EP-4292662-A2 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | Vanderbilt University (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20020049239-A1 | Novel indole and benzothiazole derivatives | SYNAPTIC PHARMACEUTICAL CORPORATION | 2002-04-25 | — | — | US | disclosed |
| US-6303643-B1 | THERAPY OF MIGRAINE HEADACHE, HYPERTENSION, ALCOHOL WITHDRAWAL, DRUG ADDICTION, RHEUMATOID ARTHRITIS, PRESBYOPIA, ISCHEMIC PAIN, SPASTICITY, DIARRHEA, NASAL CONGESTION, AND URINARY INCONTINENCE BY ADMINISTERING BENZOTHIAZOLE DERIVATIVE | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-10-16 | — | — | US | disclosed |
| EP-0900080-A4 | NOVEL INDOLE AND BENZOTHIAZOLE DERIVATIVES | SYNAPTIC PHARMA CORP (US) | 2000-12-13 | — | — | EP | disclosed |
| US-6159998-A | Substituted indoles and uses thereof | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| US-6040451-A | USED AS ANALGESIC, SEDATIVE AND ANAESTHETIC AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-21 | — | — | US | disclosed |
| US-5948804-A | ANAESTHETIC PREMEDICATION | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1999-09-07 | — | — | US | disclosed |
| US-5929094-A | NOVEL 3-((SUBSTITUTED) HETEROCYCLE),6-(SUBSTITUTED PHENYL)-1-OXASPIRO(4.4)NONANE DERIVATIVES; ANTAGONIZING THE EFFECT OF SUBSTANCE P BY ADMINISTERING TO BLOCK NEUROKININ-1 RECEPTORS; TREATING INFLAMMATION, MIGRAINE, EMESIS AND ASTHMA | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0900080-A1 | NOVEL INDOLE AND BENZOTHIAZOLE DERIVATIVES | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5677321-A | ANESTHETIC PREMEDICATION | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-10-14 | — | — | US | disclosed |
| WO-1997031636-A1 | NOVEL INDOLE AND BENZOTHIAZOLE DERIVATIVES | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240150362-A1 | Substituted Pyrrolotriazines | USP7, UBA7, USP5 | ALDH1A1 1836/4885GLA 3343/4885CYP3A4 3647/4885 |
| US-12144816-B2 | Substituted indole Mcl-1 inhibitors | MCL1, BCL2L1, BCL9 | ALDH1A1 2556/4885GLA 3582/4885CYP3A4 4659/4885 |
| US-20250263399-A1 | CBL-B MODULATORS AND USES THEREOF | CBLB, CBL, CBLC | ALDH1A1 4641/4885GLA 3277/4885CYP3A4 4648/4885 |
| US-20020049239-A1 | Novel indole and benzothiazole derivatives | ADRB2, ADRB1, CNR2 | ALDH1A1 456/4885GLA 4381/4885CYP3A4 506/4885 |
| US-12325697-B2 | CBL-B modulators and uses thereof | CBLB, CBL, CBLC | ALDH1A1 4641/4885GLA 3277/4885CYP3A4 4648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.