Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP4 | P49662 | 1/20 | 0.50 |
| ▸ | CASP5 | P51878 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 11/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 11/20 | 0.47 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921433 | 0.92 | KDM4E (0.63) | KDM4EALDH1A1HRH1USP2SMN1; SMN2 | |
| SCHEMBL1254909 | 0.82 | ALDH1A1 (0.81) | KDM4EALDH1A1HRH1USP2SMN1; SMN2 | |
| SCHEMBL3195427 | 0.81 | SORD (0.43) | KDM4EALDH1A1HRH1USP2SMN1; SMN2 | |
| SCHEMBL9803609 | 0.81 | SORD (0.43) | KDM4EALDH1A1HRH1USP2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27146448 | 0.81 | ALDH1A1 (0.85) | KDM4EALDH1A1HRH1USP2SMN1; SMN2 | |
| SCHEMBL3185465 | 0.79 | SORD (0.42) | KDM4EHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL3197967 | 0.79 | SORD (0.42) | KDM4EHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL724177 | 0.79 | SORD (0.42) | KDM4EHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL3198845 | 0.79 | SORD (0.42) | KDM4EHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL3192090 | 0.79 | SORD (0.42) | KDM4EHRH1USP2SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686373-B2 | ANALGESICS; ANTIINFLAMMATORY AGENT | WARNER-LAMBERT COMPANY LLC | 2004-02-03 | — | — | US | disclosed |
| US-20030130277-A1 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | KAWAMURA KIYOSHI (JP) | 2003-07-10 | — | — | US | disclosed |
| EP-1310498-A2 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | PFIZER INC. (US) | 2003-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130277-A1 | Pyrazoloquinolinone derivatives as protein kinase C inhibitors | PRKCB, PRKCA, PRKCG | KDM4E 1349/4885ALDH1A1 3069/4885HRH1 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.