Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.94 |
| ▸ | NPC1 | O15118 | 2/20 | 0.94 |
| ▸ | TP53 | P04637 | 1/20 | 0.85 |
| ▸ | RAB9A | P51151 | 1/20 | 0.85 |
| ▸ | POLB | P06746 | 3/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | RAD52 | P43351 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11147683 | 0.98 | ALDH1A1 (0.90) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL6893687 | 0.91 | ALDH1A1 (0.79) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL7736294 | 0.91 | ALDH1A1 (0.78) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL5334244 | 0.87 | ALDH1A1 (0.97) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL14192211 | 0.86 | ALDH1A1 (0.72) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL5925560 | 0.85 | NPC1 (0.73) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL14537720 | 0.85 | TSHR (0.75) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL8009141 | 0.85 | ALDH1A1 (0.69) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL13070618 | 0.85 | NPC1 (0.72) | ALDH1A1KDM4ENPC1TP53RAB9A | |
| SCHEMBL27402246 | 0.84 | GAA (0.77) | ALDH1A1KDM4ENPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507212-B1 | PROCESS FOR PREPARING METHYL PHENIDATE HYDROCHLORIDE | HARMAN FINOCHEM LTD (IN) | 2014-04-16 | — | — | EP | claimed |
| EP-3350182-B1 | NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION | NAT INST BIOTECHNOLOGY NEGEV LTD (IL) | 2020-06-03 | — | — | EP | disclosed |
| US-20170247383-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USING THE SAME | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-31 | — | — | US | disclosed |
| EP-2852573-B1 | N-[3-(2-CARBOXYETHYL)PHENYL]-PIPERIDIN-1-YL ACETAMIDE DERIVATIVES AND THEIR USE AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Pharma AG (DE) | 2017-02-01 | — | — | EP | disclosed |
| US-9309198-B2 | N-[3-(2-carboxyethyl)phenyl]piperidin-1-ylacetamide derivatives and use thereof as activators of soluble guanylate cyclase | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-04-12 | — | — | US | disclosed |
| US-20150152050-A1 | N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-06-04 | — | — | US | disclosed |
| EP-2852573-A1 | N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Pharma Aktiengesellschaft (DE) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013174736-A1 | N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2013-11-28 | — | — | WO | disclosed |
| US-6743794-B2 | MULTIDRUG RESISTANCE PROTEIN; CANCER; 3-(9-CHLORO-3-METHYL-4-OXO-5H-ISOXAZOLO(4,3-C)QUINOLIN-5-YL)) CYCLOHEXYL)-2-PIPERIDYLACETAMIDE | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |
| US-4581056-A | Synergistic senescence delaying foliar fertilizer composition and method of using same to delay senescence in field crops | THE BOARD OF REGENTS OF UNIVERSITY OF MICHIGAN, CORP. OF MICHIGAN (US) | 1986-04-08 | — | — | US | disclosed |
| US-4244962-A | FOR PLANTS | CIBA-GEIGY CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247383-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USING THE SAME | GAP43, PNMT, SLC6A3 | ALDH1A1 281/4885KDM4E 2259/4885NPC1 1108/4885 |
| US-20150152050-A1 | N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | GUCY1A2, GUCY1A1, GUCY1B2 | ALDH1A1 1040/4885KDM4E 2173/4885NPC1 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.