Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 4/20 | 0.33 |
| ▸ | ANPEP | P15144 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301765 | 1.00 | TSHR (0.36) | TSHRMMP2ANPEPATMMEN1 | |
| SCHEMBL8983770 | 1.00 | TSHR (0.36) | TSHRMMP2ANPEPATMMEN1 | |
| SCHEMBL3307394 | 1.00 | TSHR (0.36) | TSHRMMP2ANPEPATMMEN1 | |
| SCHEMBL8866598 | 0.90 | MMP2 (0.39) | TSHRMMP2ANPEP | |
| SCHEMBL8867224 | 0.90 | MMP2 (0.39) | TSHRMMP2ANPEP | |
| SCHEMBL13390232 | 0.89 | TSHR (0.36) | TSHRMMP2ANPEPTHRB | |
| SCHEMBL3304315 | 0.87 | HSD17B10 (0.38) | — | |
| SCHEMBL3301971 | 0.87 | HSD17B10 (0.38) | — | |
| SCHEMBL6607994 | 0.86 | AGTR2 (0.35) | TSHRMEN1KMT2A | |
| SCHEMBL25475425 | 0.84 | ALDH1A1 (0.32) | TSHRMMP2ANPEPKMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082606-A1 | Excitatory amino acid receptor antagonists | KHAU VIEN VAN (US) | 2004-04-29 | — | — | US | disclosed |
| EP-1351955-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6579886-B2 | Ionotropic glutamate receptors; 6-((4-carboxylic acid-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3 -carboxylic acid | ELI LILLY AND COMPANY | 2003-06-17 | — | — | US | disclosed |
| US-20030055081-A1 | Selective iglur5 receptor antagonists | ELI LILLY AND COMPANY | 2003-03-20 | — | — | US | disclosed |
| EP-1257545-A1 | SELECTIVE iGLUR 5? RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2002053561-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-07-11 | — | — | WO | disclosed |
| WO-2001046173-A1 | SELECTIVE iGLUR5 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082606-A1 | Excitatory amino acid receptor antagonists | SLC1A2, SLC1A1, SLC1A3 | TSHR 375/4885MMP2 4225/4885ANPEP 610/4885 |
| US-20030055081-A1 | Selective iglur5 receptor antagonists | GRM5, GRIK5, GPR35 | TSHR 836/4885MMP2 4540/4885ANPEP 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.