Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.51 |
| ▸ | FNTB | P49356 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | SCN2B | O60939 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679956 | 0.89 | MAPK14 (0.55) | ALDH1A1GAASCN9AMAPK14SCN3A | |
| SCHEMBL680489 | 0.85 | SCN3A (0.45) | SCN9ASCN3ASCN2BSCN1ASCN1B | |
| SCHEMBL679939 | 0.81 | MEN1 (0.60) | ALDH1A1GAASCN9ASCN3AEZH2 | |
| SCHEMBL680339 | 0.80 | KMT2A (0.51) | ALDH1A1POLBGAASCN9ASCN3A | |
| SCHEMBL681087 | 0.80 | SCN9A (0.54) | SCN9ASCN3ASCN2BSCN1BSCN5A | |
| SCHEMBL680618 | 0.80 | MAPK14 (0.54) | SCN9AMAPK14SCN3AEZH2LMNA | |
| SCHEMBL680159 | 0.80 | CXCL8 (0.59) | SCN9ASCN3ASCN2BSCN1BSCN5A | |
| SCHEMBL10825678 | 0.79 | DHFR (0.54) | ALDH1A1POLBGAACRHBPFNTA | |
| SCHEMBL680346 | 0.79 | SCN9A (0.57) | SCN9ASCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL679137 | 0.79 | RORC (0.52) | SCN9AMAPK14SCN3ASCN5APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | ALDH1A1 643/4885POLB 4438/4885GAA 3927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.