Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 4/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3084518 | 0.77 | SPHK2 (0.42) | FDPSSPHK2SPHK1NOS3NOS1 | |
| SCHEMBL7259933 | 0.75 | FDPS (0.46) | FDPSSMPD1CA1CA2CES2 | |
| SCHEMBL12344214 | 0.73 | CES2 (0.42) | FDPSSPHK2SPHK1NOS3NOS1 | |
| SCHEMBL9067900 | 0.72 | FDPS (0.48) | FDPSSMPD1CES2CES1 | |
| SCHEMBL22345607 | 0.72 | FDPS (0.39) | FDPSSPHK2SPHK1NOS3NOS1 | |
| SCHEMBL8912936 | 0.71 | SPHK2 (0.48) | SPHK2SPHK1 | |
| SCHEMBL288685 | 0.70 | FDPS (0.46) | FDPSSMPD1ESR1MEN1KMT2A | |
| SCHEMBL1714767 | 0.70 | FDPS (0.46) | FDPSSMPD1CES2CES1MEN1 | |
| Hydrochloric Acid SCHEMBL10778963 | 0.69 | ALDH1A1 (0.43) | FDPSSPHK2SPHK1NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL10778967 | 0.69 | ALDH1A1 (0.43) | FDPSSPHK2SPHK1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750211-B2 | PREFERRED DERIVATIVE IS A NATURALLY OCCURING 2,6-BIS-(OMEGA-AMINOBUTYL)-3,5-DIIMINOPIPERAZINE; INHIBITION OF SPHINGOLIPID METABOLISM BY SUPPRESSING THE ?BURST?; ANTI- CARCINOGENIC, -INFLAMMATORY AGENTS; HEART ATTACK; STROKE | EMORY UNIVERSITY | 2004-06-15 | — | — | US | disclosed |
| US-20030166666-A1 | Diimino-piperazine derivatives for use as modulators of cell regulation | MERRILL ALFRED H (US) | 2003-09-04 | — | — | US | disclosed |
| US-6552025-B1 | As inhibitors of sphingolipid metabolism; for therapy | EMORY UNIVERSITY | 2003-04-22 | — | — | US | disclosed |
| WO-2001037836-A1 | DIIMINO-PIPERAZINE DERIVATIVES FOR USE AS MODULATORS OF CELL REGULATION | EMORY UNIVERSITY (US) | 2001-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166666-A1 | Diimino-piperazine derivatives for use as modulators of cell regulation | SMPD2, SGMS2, SPTLC2 | FDPS 715/4885SPHK2 9/4885SPHK1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.