Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | SMPD2 | O60906 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173509 | 0.83 | TSHR (0.42) | AKR1B1KCNJ11ALDH1A1G6PDUSP2 | |
| SCHEMBL11190798 | 0.83 | TSHR (0.42) | AKR1B1KCNJ11ALDH1A1G6PDUSP2 | |
| SCHEMBL7596368 | 0.83 | TSHR (0.42) | AKR1B1KCNJ11ALDH1A1G6PDUSP2 | |
| SCHEMBL1627739 | 0.82 | KCNJ11 (0.43) | AKR1B1KCNJ11ALDH1A1NCEH1G6PD | |
| SCHEMBL1818692 | 0.81 | ALDH1A1 (0.47) | AKR1B1ALDH1A1USP2LMNAHSD17B10 | |
| SCHEMBL1818689 | 0.81 | ALDH1A1 (0.47) | AKR1B1ALDH1A1USP2LMNAHSD17B10 | |
| SCHEMBL6113114 | 0.81 | WDR5 (0.42) | AKR1B1KCNJ11ALDH1A1NCEH1G6PD | |
| Acetic Acid SCHEMBL29643381 | 0.81 | S1PR4 (0.40) | AKR1B1KCNJ11ALDH1A1G6PDUSP2 | |
| SCHEMBL7353058 | 0.78 | CA12 (0.44) | KCNJ11ALDH1A1NCEH1G6PDHSD17B10 | |
| SCHEMBL8149658 | 0.77 | G6PD (0.47) | AKR1B1ALDH1A1G6PDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969288-B2 | Amide based glucagon and superfamily peptide prodrugs | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2015-03-03 | — | — | US | claimed |
| CN-102325539-A | Amide based glucagon superfamily peptide prodrugs | UNIV INDIANA RES & TECH CORP | 2012-01-18 | — | — | CN | claimed |
| US-20110288003-A1 | AMIDE BASED GLUCAGON AND SUPERFAMILY PEPTIDE PRODRUGS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2011-11-24 | — | — | US | claimed |
| EP-2376097-A1 | AMIDE BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS | Indiana University Research and Technology Corporation (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010071807-A1 | AMIDE BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2010-06-24 | — | — | WO | claimed |
| JP-2009529509-A | — | — | 2009-08-20 | — | — | JP | claimed |
| EP-2007791-A2 | MODIFIED MOLECULES WHICH PROMOTE HEMATOPOIESIS | AplaGen GmbH (DE) | 2008-12-31 | — | — | EP | claimed |
| WO-2007101698-A2 | MODIFIED MOLECULES WHICH PROMOTE HEMATOPOIESIS | APLAGEN GMBH (DE) | 2007-09-13 | — | — | WO | claimed |
| CN-108137676-B | gp120 neutralizing antibodies and uses thereof | 美国政府(由卫生和人类服务部的部长所代表) | 2022-03-15 | — | — | CN | disclosed |
| EP-2654773-B1 | GLUCAGON ANALOGS EXHIBITING GIP RECEPTOR ACTIVITY | UNIV INDIANA RES & TECH CORP (US) | 2018-10-03 | — | — | EP | disclosed |
| US-20180105569-A1 | ANALOGS OF GLUCAGON EXHIBITING GIP RECEPTOR ACTIVITY | UNIV INDIANA RES & TECH CORP (US) | 2018-04-19 | — | — | US | disclosed |
| EP-2864350-B1 | ANALOGS OF GLUCAGON EXHIBITING GIP RECEPTOR ACTIVITY | UNIV INDIANA RES & TECH CORP (US) | 2018-03-28 | — | — | EP | disclosed |
| US-9868772-B2 | Analogs of glucagon exhibiting GIP receptor activity | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2018-01-16 | — | — | US | disclosed |
| US-9587005-B2 | Glucagon analogs exhibiting GIP receptor activity | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2017-03-07 | — | — | US | disclosed |
| US-20110237493-A1 | DIPEPTIDE LINKED MEDICINAL AGENTS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2011-09-29 | — | — | US | disclosed |
| WO-2010080605-A1 | DIPEPTIDE LINKED MEDICINAL AGENTS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2010-07-15 | — | — | WO | disclosed |
| WO-2010071807-A1 | AMIDE BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2010-06-24 | — | — | WO | disclosed |
| US-20090281278-A1 | MODIFIED MOLECULES WHICH PROMOTE HEMATOPOIESIS | APLAGEN GMBH (DE) | 2009-11-12 | — | — | US | disclosed |
| EP-2007791-A2 | MODIFIED MOLECULES WHICH PROMOTE HEMATOPOIESIS | AplaGen GmbH (DE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007101698-A2 | MODIFIED MOLECULES WHICH PROMOTE HEMATOPOIESIS | APLAGEN GMBH (DE) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281278-A1 | MODIFIED MOLECULES WHICH PROMOTE HEMATOPOIESIS | EPOR, MPL, THPO | AKR1B1 4271/4885KCNJ11 4870/4885ALDH1A1 2893/4885 |
| US-20180105569-A1 | ANALOGS OF GLUCAGON EXHIBITING GIP RECEPTOR ACTIVITY | GLP1R, GIPR, GCGR | AKR1B1 1504/4885KCNJ11 2766/4885ALDH1A1 4105/4885 |
| US-20110288003-A1 | AMIDE BASED GLUCAGON AND SUPERFAMILY PEPTIDE PRODRUGS | GCG, GLP1R, IAPP | AKR1B1 753/4885KCNJ11 4444/4885ALDH1A1 2679/4885 |
| US-20110237493-A1 | DIPEPTIDE LINKED MEDICINAL AGENTS | DNPEP, PEPD, CNDP2 | AKR1B1 3253/4885KCNJ11 4770/4885ALDH1A1 2146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.