Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.36 |
| ▸ | HTR1B | P28222 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1400482 | 0.74 | P2RX7 (0.38) | HTR1DHTR1BALDH1A1AHRUSP2 | |
| SCHEMBL31005469 | 0.74 | P2RX7 (0.38) | HTR1DHTR1BALDH1A1AHRUSP2 | |
| SCHEMBL4623327 | 0.73 | ALDH1A1 (0.53) | HTR1DHTR1BALDH1A1PKMGAA | |
| SCHEMBL1876842 | 0.73 | TYR (0.40) | ALDH1A1AHRUSP2GAAALOX15 | |
| Hydrochloric Acid SCHEMBL27467897 | 0.72 | P2RX7 (0.38) | HTR1DHTR1BALDH1A1AHRUSP2 | |
| SCHEMBL2503153 | 0.69 | RHEB (0.40) | AHRUSP2GAAALOX15RAD51 | |
| SCHEMBL4388854 | 0.69 | AHR (0.47) | ALDH1A1AHRUSP2GAAALOX15 | |
| SCHEMBL8813845 | 0.69 | TYR (0.38) | ALDH1A1AHRUSP2GAAALOX15 | |
| SCHEMBL1401673 | 0.69 | P4HB (0.42) | ALDH1A1AHRUSP2GAAALOX15 | |
| SCHEMBL13904855 | 0.69 | AHR (0.38) | ALDH1A1AHRUSP2GAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6812228-B2 | TREATMENT OF PROGRESSIVE NEURODEGENERATIVE MOVEMENT DISORDERS CHARACTERIZED BY HYPOKINESIA, TREMOR, AND MUSCULAR RIGIDITY | WARNER-LAMBERT COMPANY | 2004-11-02 | — | — | US | disclosed |
| EP-1282625-B1 | BENZOXAZINES FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE | WARNER LAMBERT CO (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20030220335-A1 | Benzoxazines for use in the treatment of parkinson's disease | WARNER-LAMBERT COMPANY | 2003-11-27 | — | — | US | disclosed |
| EP-1282625-A1 | BENZOXAZINES FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE | WARNER-LAMBERT COMPANY (US) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001085734-A1 | BENZOXAZINES FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE | WARNER-LAMBERT COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220335-A1 | Benzoxazines for use in the treatment of parkinson's disease | PARK7, HAX1, SNCA | HTR1D 30/4885HTR1B 21/4885ALDH1A1 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.