Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.31 |
| ▸ | MERTK | Q12866 | 2/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6813739 | 0.82 | DYRK1A (0.38) | KMT5AACP1JAK2JAK1JAK3 | |
| SCHEMBL6081983 | 0.76 | CRHR1 (0.35) | — | |
| SCHEMBL6081981 | 0.76 | CRHR1 (0.35) | — | |
| SCHEMBL6818798 | 0.75 | ABL1 (0.36) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL6814839 | 0.74 | CRHR1 (0.39) | KMT5AGALR3JAK2JAK1JAK3 | |
| SCHEMBL6813821 | 0.73 | LMNA (0.35) | PIK3CAKMT5AACP1 | |
| SCHEMBL6082233 | 0.72 | TP53 (0.37) | PIK3CA | |
| SCHEMBL6082225 | 0.72 | TP53 (0.37) | PIK3CA | |
| SCHEMBL6082359 | 0.72 | NNMT (0.40) | PIK3CAMAP4K1 | |
| SCHEMBL6082485 | 0.71 | CRHR1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |