SCHEMBL682183

SCHEMBL682183

O=C(O)C(Cl)(Cl)CCCCCCCCCCc1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HDAC9 Q9UKV0 1/20 0.49
HDAC5 Q9UQL6 1/20 0.49
PLAAT3 P53816 1/20 0.47
PLAAT5 Q96KN8 1/20 0.47
PLAAT2 Q9NWW9 1/20 0.47
PLAAT4 Q9UL19 1/20 0.47
LTB4R Q15722 2/20 0.45
IGF1R P08069 1/20 0.45
ALOX15 P16050 1/20 0.45
PPARA Q07869 2/20 0.43
PPARG P37231 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7620776 1.00 HDAC3 (0.49) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL7615412 1.00 HDAC3 (0.49) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL9056155 0.93 S1PR2 (0.46) HDAC1LTB4RS1PR2S1PR4S1PR1
SCHEMBL4661178 0.93 HDAC3 (0.50) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL8463990 0.91 HDAC3 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL7613532 0.91 S1PR2 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL7616376 0.91 S1PR2 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4662607 0.90 ACACB (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL7623903 0.89 PLAAT3 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL3676720 0.86 HDAC3 (0.43) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 564 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3199203-B1 SUBSTITUTED XANTHINE DERIVATIVES CONCERT PHARMACEUTICALS INC (US) 2020-02-05 EP claimed
EP-1772149-A1 DRUG FOR PREVENTION OR TREATMENT OF DIABETES Kowa Company. Ltd. (JP) 2007-04-11 EP claimed
EP-1752147-A1 DRUG FOR PREVENTION OR TREATMENT OF DIABETES Kowa Company Ltd. (JP) 2007-02-14 EP claimed
EP-1747780-A1 DRUG FOR PREVENTION OR TREATMENT OF DIABETES KOWA COMPANY, LTD. (JP) 2007-01-31 EP claimed
US-20060051410-A1 Pharmaceutical composition containing 2,2-dichloro-12-(4-chlorophenyl)-dodecanoic acid KOWA COMPANY, LTD. (JP) 2006-03-09 US claimed
US-20060025478-A1 Medicine for prevention or treatment of diabetes KOWA COMPANY, LTD. (JP) 2006-02-02 US claimed
US-20050272814-A1 Medicine for prevention or treatment of diabetes KOWA COMPANY, LTD. (JP) 2005-12-08 US claimed
US-20050261349-A1 Medicine for prevention or treatment of diabetes KOWA COMPANY, LTD. (JP) 2005-11-24 US claimed
EP-1473033-A1 MEDICINAL COMPOSITION CONTAINING 2,2-DICHLORO-12-(4-CHLOROPHENYL)DODECANOIC ACID Kowa Company Ltd. (JP) 2004-11-03 EP claimed
EP-0790824-B1 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE ROCHE DIAGNOSTICS GMBH (DE) 2002-02-06 EP claimed
US-5968982-A TREATMENT OF DIABETES ROCHE DIAGNOSTICS GMBH (DE) 1999-10-19 US claimed
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2023-07-06 US disclosed
US-11007162-B2 Methods of reducing small, dense LDL particles CYMABAY THERAPEUTICS, INC. (US) 2021-05-18 US disclosed
US-20190298672-A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES CYMABAY THERAPEUTICS, INC. (US) 2019-10-03 US disclosed
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2019-06-27 US disclosed
US-20030045553-A1 Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators ORTHO-MCNEIL PHARMACEUITCAL, INC. 2003-03-06 US disclosed
EP-0790824-B1 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE ROCHE DIAGNOSTICS GMBH (DE) 2002-02-06 EP disclosed
US-5968982-A TREATMENT OF DIABETES ROCHE DIAGNOSTICS GMBH (DE) 1999-10-19 US disclosed
EP-0790824-A1 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE Roche Diagnostics GmbH (DE) 1997-08-27 EP disclosed
WO-1996015784-A2 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE BOEHRINGER MANNHEIM GMBH (DE) 1996-05-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190298672-A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES LDLR, APOB, HDLBP HDAC3 96/4885HDAC4 293/4885HDAC1 308/4885
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD HDAC3 83/4885HDAC4 230/4885HDAC1 445/4885
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD HDAC3 83/4885HDAC4 230/4885HDAC1 445/4885
US-11007162-B2 Methods of reducing small, dense LDL particles LDLR, APOB, HDLBP HDAC3 96/4885HDAC4 293/4885HDAC1 308/4885
US-20030045553-A1 Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators GPR119, SLC2A4, PPARG HDAC3 938/4885HDAC4 996/4885HDAC1 1869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.