Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.56 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 2/20 | 0.45 |
| ▸ | PYGM | P11217 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820557 | 0.83 | TAS1R3 (0.52) | TAS1R3TAS1R2HDAC8MEN1KMT2A | |
| SCHEMBL6824779 | 0.77 | SMYD3 (0.56) | TAS1R3TAS1R2HDAC8MEN1KMT2A | |
| SCHEMBL30818640 | 0.76 | TAS1R3 (0.48) | TAS1R3TAS1R2HDAC8MEN1KMT2A | |
| SCHEMBL28684619 | 0.76 | NPC1 (0.66) | TAS1R3TAS1R2MEN1KMT2AKDM4E | |
| SCHEMBL6823902 | 0.75 | OPRK1 (0.54) | MEN1KMT2A | |
| SCHEMBL8022128 | 0.74 | KMO (0.59) | TAS1R3TAS1R2MEN1KMT2AKDM4E | |
| SCHEMBL700604 | 0.71 | TAS1R3 (1.00) | TAS1R3TAS1R2TAS1R1 | |
| SCHEMBL6820720 | 0.71 | DPP4 (0.55) | TAS1R3TAS1R2HDAC8MEN1KMT2A | |
| SCHEMBL3454744 | 0.71 | HSD11B1 (0.69) | TAS1R3TAS1R2MEN1KMT2AKDM4E | |
| SCHEMBL30818787 | 0.70 | KMT2A (0.55) | TAS1R3TAS1R2HDAC8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | disclosed |