Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825305 | 0.89 | ALDH1A1 (0.52) | HTTSMN1; SMN2NPC1HPGDMAPT | |
| SCHEMBL6825631 | 0.85 | LMNA (0.58) | HTTSMN1; SMN2NPC1KMT2AMAPT | |
| SCHEMBL6828519 | 0.84 | RXFP1 (0.58) | HTTSMN1; SMN2NPC1HPGDMEN1 | |
| SCHEMBL6828555 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1MEN1KMT2APOLB | |
| SCHEMBL6828200 | 0.81 | ROCK2 (0.57) | SMN1; SMN2HPGDPOLBROCK2ROCK1 | |
| SCHEMBL6828221 | 0.81 | LMNA (0.57) | HTTSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL6828203 | 0.78 | MAPT (0.60) | HTTSMN1; SMN2NPC1HPGDMEN1 | |
| SCHEMBL6825636 | 0.78 | EPHX2 (0.55) | SMN1; SMN2NPC1MEN1KMT2AMAPT | |
| SCHEMBL6830213 | 0.77 | KDM4E (0.59) | HTTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL6828198 | 0.76 | MAPT (0.60) | HTTSMN1; SMN2NPC1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138269-A1 | Substituted pyrroles as kinase inhibitors | SUGEN, INC. | 2004-07-15 | — | — | US | claimed |
| US-20040138269-A1 | Substituted pyrroles as kinase inhibitors | SUGEN, INC. | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138269-A1 | Substituted pyrroles as kinase inhibitors | PHKG1, PHKG2, MAP3K20 | HTT 1942/4885SMN1; SMN2 2661/4885NPC1 2915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.