Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825993 | 0.85 | ADORA3 (0.45) | HPGDSALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL6828337 | 0.84 | CHEK1 (0.40) | ALDH1A1HSD17B10HPGDKDM4ECYP2C9 | |
| SCHEMBL6828733 | 0.82 | HPGDS (0.47) | HPGDSPTGS2ALDH1A1HSD17B10HPGD | |
| SCHEMBL6828438 | 0.82 | L3MBTL1 (0.43) | HSD17B10SMN1; SMN2 | |
| SCHEMBL6133301 | 0.81 | ALDH1A1 (0.49) | HPGDSPTGS2ALDH1A1HSD17B10HPGD | |
| SCHEMBL6829284 | 0.80 | MAPK8 (0.43) | HPGDMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6829256 | 0.77 | HPGD (0.39) | HPGDSALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL6825783 | 0.76 | ADORA1 (0.56) | ALDH1A1HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6828463 | 0.76 | ADORA3 (0.46) | HPGDSALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL6828830 | 0.76 | ADORA2A (0.48) | ALDH1A1HSD17B10HPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |