Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | ACR | P10323 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TACR2 | P21452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828337 | 0.91 | CHEK1 (0.40) | ADORA3ADORA2AADORA2BADORA1HPGD | |
| SCHEMBL6828463 | 0.88 | ADORA3 (0.46) | ADORA3ADORA2AADORA2BADORA1ALOX15 | |
| SCHEMBL6829284 | 0.86 | MAPK8 (0.43) | ADORA2AADORA1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL6828438 | 0.86 | L3MBTL1 (0.43) | TSHRSMN1; SMN2PDE2A | |
| SCHEMBL6828786 | 0.85 | HPGDS (0.49) | ADORA3HPGDCYP1A2SMN1; SMN2RAB9A | |
| SCHEMBL6830662 | 0.83 | ADORA3 (0.41) | ADORA3ADORA2AADORA2BADORA1ALOX15 | |
| SCHEMBL6133796 | 0.82 | ADORA2A (0.50) | ADORA3ADORA2AADORA2BADORA1ALOX15 | |
| SCHEMBL6828357 | 0.79 | ADORA2A (0.51) | ADORA3ADORA2AADORA2BADORA1XIAP | |
| SCHEMBL6829256 | 0.79 | HPGD (0.39) | ADORA3ADORA2AADORA1HPGDSMN1; SMN2 | |
| SCHEMBL6828483 | 0.79 | XIAP (0.44) | ADORA3ADORA2AADORA1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |