Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | XIAP | P98170 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825993 | 0.91 | ADORA3 (0.45) | HPGDXIAPPTGS1ALDH1A1RAB9A | |
| SCHEMBL6828438 | 0.87 | L3MBTL1 (0.43) | RETGSK3BAURKBCLK4HSD17B10 | |
| SCHEMBL6829284 | 0.87 | MAPK8 (0.43) | PIM1RPS6KA3AURKBCLK4HPGD | |
| SCHEMBL6828786 | 0.84 | HPGDS (0.49) | HPGDALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL6828357 | 0.80 | ADORA2A (0.51) | XIAPNPSR1MAPTHTTRAB9A | |
| SCHEMBL6829256 | 0.80 | HPGD (0.39) | HPGDXIAPPTGS1ALDH1A1KDM4E | |
| SCHEMBL6830337 | 0.79 | ADORA2A (0.50) | XIAPALDH1A1KDM4ERAB9AADORA3 | |
| SCHEMBL6826020 | 0.79 | NPC1 (0.48) | HPGDXIAPALDH1A1NPSR1KDM4E | |
| SCHEMBL6828483 | 0.79 | XIAP (0.44) | HPGDXIAPALDH1A1NPSR1KDM4E | |
| SCHEMBL6830646 | 0.79 | ADORA2A (0.53) | GSK3BHPGDXIAPALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |