Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28296124 | 0.80 | GAA (0.35) | MTNR1AMTNR1BALDH1A1OPRM1OPRK1 | |
| SCHEMBL7995094 | 0.77 | ALDH1A1 (0.36) | MTNR1AMTNR1BALDH1A1F2 | |
| SCHEMBL3240481 | 0.70 | PDE5A (0.37) | KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL6831395 | 0.68 | KMT2A (0.59) | OPRM1OPRK1 | |
| SCHEMBL28873839 | 0.67 | GAA (0.39) | KCNH2SCN3AALDH1A1OPRM1 | |
| SCHEMBL7099613 | 0.67 | GAA (0.36) | HTR2AKCNH2SCN3AKDM4ELMNA | |
| SCHEMBL5740073 | 0.65 | PDE5A (0.37) | KDM4EALDH1A1OPRM1OPRK1 | |
| SCHEMBL10505998 | 0.65 | MAPT (0.47) | MTNR1AMTNR1BKDM4EALDH1A1OPRM1 | |
| SCHEMBL9631444 | 0.62 | MAPT (0.47) | KDM4EOPRM1 | |
| SCHEMBL5319112 | 0.61 | SLC22A1 (0.50) | KDM4EOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770656-B2 | NEURODEGENERATIVE DISORDERS; ANTIEPILEPTIC AND ANTIISCHEMIC AGENTS; INFERTILITY, CARDIOVASCULAR DISORDERS, RENAL HYPOXIA, HEPATITIS AND AIDS TREATMENT | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2004-08-03 | — | — | US | disclosed |