Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PYGL | P06737 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196937 | 0.85 | IDO1 (0.46) | POLBKMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL20560246 | 0.83 | POLB (0.52) | POLBKMT2AALOX15ALDH1A1MAPT | |
| SCHEMBL4491417 | 0.81 | KMT2A (0.48) | POLBKMT2AALOX15MAPTPYGL | |
| SCHEMBL140667 | 0.81 | LMNA (0.53) | KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL29639366 | 0.81 | LMNA (0.53) | KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL653172 | 0.81 | ALDH1A1 (0.61) | KMT2AALDH1A1MAPTNPC1NPSR1 | |
| SCHEMBL29639365 | 0.81 | ALDH1A1 (0.61) | KMT2AALDH1A1MAPTNPC1NPSR1 | |
| SCHEMBL11880754 | 0.79 | ALOX15 (0.47) | POLBKMT2AALOX15MAPTPYGL | |
| SCHEMBL5525050 | 0.78 | SIGMAR1 (0.50) | POLBKMT2AALDH1A1MAPT | |
| SCHEMBL11164506 | 0.78 | RAB9A (0.51) | POLBKMT2AALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467981-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | Kylix Pharmaceuticals B.V. (NL) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062215-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | KYLIX PHARMACEUTICALS B.V. (NL) | 2003-07-31 | — | — | WO | disclosed |