SCHEMBL6834101

SCHEMBL6834101

N#Cc1ccc(NC(=O)c2cc3ccc(Cl)cc3[nH]2)c(C(=O)O)c1

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NHERF1 O14745 2/20 0.56
ALOX15 P16050 6/20 0.51
SERPINE1 P05121 3/20 0.45
PRSS12 P56730 2/20 0.44
PPARG P37231 1/20 0.44
PPARA Q07869 1/20 0.44
ALB P02768 1/20 0.43
CNR2 P34972 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6834022 0.85 NPC1 (0.55) NHERF1
SCHEMBL6834270 0.80 FLT3 (0.50) NHERF1
SCHEMBL19554161 0.80 CA2 (0.56) SERPINE1ALB
SCHEMBL6830559 0.80 NHERF1 (0.45) NHERF1SERPINE1PRSS12ALB
SCHEMBL6835708 0.79 CCKAR (0.51) NHERF1
SCHEMBL6708816 0.78 ALOX15 (0.44) NHERF1ALOX15CNR2
SCHEMBL6833112 0.78 KDM4E (0.57) NHERF1
SCHEMBL6711774 0.78 ALOX15 (0.43) NHERF1ALOX15CNR2
SCHEMBL6830511 0.76 NHERF1 (0.44) NHERF1SERPINE1ALB
SCHEMBL6834079 0.76 NHERF1 (0.44) NHERF1SERPINE1ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US claimed
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110802-A1 Antibacterial benzoic acid derivatives GABRD, GABBR1, GABRA1 NHERF1 1142/4885ALOX15 697/4885SERPINE1 1860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.