Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2641981 | 0.86 | FGFR1 (0.56) | HPGDALDH1A1FGFR1GABRA1GABRG2 | |
| Hydrochloric Acid SCHEMBL2641992 | 0.85 | FGFR1 (0.54) | HPGDALDH1A1FGFR1GABRA1GABRG2 | |
| SCHEMBL2641983 | 0.81 | GABRA1 (0.55) | HPGDALDH1A1FGFR1GABRA1GABRG2 | |
| SCHEMBL2641906 | 0.79 | HPGD (0.45) | HPGDALDH1A1FGFR1GABRA1GABRG2 | |
| SCHEMBL2642002 | 0.79 | HPGD (0.46) | HPGDALDH1A1FGFR1GABRA1GABRG2 | |
| SCHEMBL19915930 | 0.78 | FGFR1 (0.62) | ALDH1A1FGFR1KDRSRC | |
| SCHEMBL2646769 | 0.77 | HTT (0.59) | HPGDALDH1A1FGFR1KDR | |
| Hydrochloric Acid SCHEMBL2642036 | 0.77 | GABRA1 (0.46) | HPGDALDH1A1FGFR1GABRA1GABRG2 | |
| Hydrochloric Acid SCHEMBL2642067 | 0.76 | HTT (0.47) | HPGDALDH1A1FGFR1KDRF9 | |
| SCHEMBL1761981 | 0.76 | GABRA1 (0.55) | HPGDALDH1A1FGFR1GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077634-A1 | Treatment of diseases characterized by excessive or insufficient cell death | NEUROSEARCH A/S (DK) | 2004-04-22 | — | — | US | claimed |
| EP-1361874-A1 | TREATMENT OF DISEASES CHARACTERIZED BY EXCESSIVE OR INSUFFICIENT CELL DEATH | NEUROSEARCH A/S (DK) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064128-A1 | TREATMENT OF DISEASES CHARACTERIZED BY EXCESSIVE OR INSUFFICIENT CELL DEATH | NEUROSEARCH A/S (DK) | 2002-08-22 | — | — | WO | claimed |
| US-20040077634-A1 | Treatment of diseases characterized by excessive or insufficient cell death | NEUROSEARCH A/S (DK) | 2004-04-22 | — | — | US | disclosed |
| EP-1361874-A1 | TREATMENT OF DISEASES CHARACTERIZED BY EXCESSIVE OR INSUFFICIENT CELL DEATH | NEUROSEARCH A/S (DK) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064128-A1 | TREATMENT OF DISEASES CHARACTERIZED BY EXCESSIVE OR INSUFFICIENT CELL DEATH | NEUROSEARCH A/S (DK) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077634-A1 | Treatment of diseases characterized by excessive or insufficient cell death | APAF1, CASP9, AIFM1 | MTOR 746/4885PIK3CA 3297/4885PIK3CD 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.