SCHEMBL6834385

SCHEMBL6834385

N#Cc1ccc(NC(=O)c2cc3cccc(NC(=O)c4ccc(-c5ccccc5)cc4)c3[nH]2)c(C(=O)O)c1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SERPINE1 P05121 2/20 0.51
DHODH Q02127 1/20 0.51
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
ALB P02768 1/20 0.46
IGF2BP2 Q9Y6M1 1/20 0.46
PRSS12 P56730 1/20 0.46
NR1H4 Q96RI1 2/20 0.46
RXFP1 Q9HBX9 1/20 0.45
PPARG P37231 2/20 0.45
PPARD Q03181 1/20 0.45
PPARA Q07869 1/20 0.45
KMT2A Q03164 1/20 0.44
PDCD1 Q15116 1/20 0.44
CD274 Q9NZQ7 1/20 0.44
SUCNR1 Q9BXA5 1/20 0.43
NHERF1 O14745 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6834154 0.95 KMT2A (0.49) SERPINE1NPC1RAB9AALBNR1H4
SCHEMBL6834115 0.91 ALB (0.47) SERPINE1ALBNR1H4RXFP1KMT2A
SCHEMBL6830877 0.90 AKR1C2 (0.48) DHODHALBNR1H4RXFP1KMT2A
SCHEMBL6833766 0.90 PARP14 (0.43) SERPINE1DHODHNR1H4PPARGPPARD
SCHEMBL6835708 0.89 CCKAR (0.51) NPC1RAB9ANHERF1
SCHEMBL6833137 0.88 MAP3K5 (0.44) ALBNR1H4RXFP1KMT2ANHERF1
SCHEMBL6830615 0.88 ALB (0.44) ALBNR1H4RXFP1KMT2A
SCHEMBL6835688 0.87 GFER (0.45) NPC1ALBNR1H4RXFP1NHERF1
SCHEMBL6348677 0.86 SERPINE1 (0.66) SERPINE1DHODHNPC1RAB9AALB
SCHEMBL6834504 0.86 LMNA (0.47) ALBRXFP1KMT2ANHERF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040110802-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110802-A1 Antibacterial benzoic acid derivatives GABRD, GABBR1, GABRA1 SERPINE1 1860/4885DHODH 166/4885NPC1 3778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.