Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | HINT1 | P49773 | 2/20 | 0.40 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.40 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.40 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9294597 | 0.93 | TYMP (0.46) | TYMPTAAR1HPGDPOLBHINT1 | |
| SCHEMBL16401149 | 0.90 | TYMP (0.45) | TYMPTAAR1HPGDPOLBXDH | |
| SCHEMBL17599868 | 0.88 | TYMP (0.43) | TYMPTAAR1HPGDPOLBXDH | |
| SCHEMBL6316021 | 0.87 | TYMP (0.39) | TYMPTAAR1HPGDPOLBXDH | |
| SCHEMBL8574965 | 0.85 | HPGD (0.46) | TYMPTAAR1HPGDPOLBXDH | |
| SCHEMBL17599828 | 0.85 | TYMP (0.49) | TYMPTAAR1HPGDXDHHINT1 | |
| SCHEMBL16401878 | 0.85 | TYMP (0.49) | TYMPTAAR1HPGDXDHHINT1 | |
| SCHEMBL7073590 | 0.84 | POLB (0.39) | TYMPTAAR1HPGDPOLBHINT1 | |
| SCHEMBL9059968 | 0.83 | TAAR1 (0.49) | TYMPTAAR1POLBHINT1P2RY2 | |
| SCHEMBL6831440 | 0.82 | TYMP (0.48) | TYMPTAAR1HPGDHINT1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030232980-A1 | Methods of producing phosphitylated compounds | HONEYWELL INTERNATIONAL INC. | 2003-12-18 | — | — | US | claimed |
| US-6414137-B1 | Selective solvent extraction for the purification of protected nucleosides | ALLIEDSIGNAL INC. | 2002-07-02 | — | — | US | claimed |
| EP-1140957-A1 | SELECTIVE SOLVENT EXTRACTION FOR THE PURIFICATION OF PROTECTED NUCLEOSIDES | AlliedSignal Inc. (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000039138-A1 | SELECTIVE SOLVENT EXTRACTION FOR THE PURIFICATION OF PROTECTED NUCLEOSIDES | ALLIEDSIGNAL INC. (US) | 2000-07-06 | — | — | WO | claimed |
| US-20230242569-A1 | PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE | 2023-08-03 | — | — | US | disclosed |
| US-20230212204-A1 | REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS | THE SCRIPPS RESEARCH INSTITUTE | 2023-07-06 | — | — | US | disclosed |
| US-11613554-B2 | Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-03-28 | — | — | US | disclosed |
| US-11548910-B2 | Oligonucleotide production method | NISSAN CHEMICAL CORPORATION (JP) | 2023-01-10 | — | — | US | disclosed |
| EP-3004131-B1 | PHOSPHORAMIDITE BUILDING BLOCKS FOR SUGAR-CONJUGATED OLIGONUCLEOTIDES | AM CHEMICALS LLC (US) | 2020-07-22 | — | — | EP | disclosed |
| US-10669301-B2 | Phosphoramidite building blocks for sugar-conjugated oligonucleotides | AM CHEMICALS LLC (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190322694-A1 | NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE | 2019-10-24 | — | — | US | disclosed |
| US-20190169223-A1 | OLIGONUCLEOTIDE PRODUCTION METHOD | NISSAN CHEMICAL CORPORATION (JP) | 2019-06-06 | — | — | US | disclosed |
| WO-2014197714-A1 | PHOSPHORAMIDITE BUILDING BLOCKS FOR SUGAR-CONJUGATED OLIGONUCLEOTIDES | AM CHEMICALS LLC (US) | 2014-12-11 | — | — | WO | disclosed |
| US-20040082774-A1 | Novel phosphate and thiophosphate protecting groups | ISIS PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-6610837-B1 | Preparation of an oligonucleotide compound of given formula by reacting with given compounds, followed by oxidation or sulfurization | ISIS PHARMACEUTICALS, INC. | 2003-08-26 | — | — | US | disclosed |
| US-6414137-B1 | Selective solvent extraction for the purification of protected nucleosides | ALLIEDSIGNAL INC. | 2002-07-02 | — | — | US | disclosed |
| EP-0711301-A4 | PROCESSES AND INTERMEDIATES FOR PHOSPHOROUS-CONTAINING COVALENT LINKAGES | ISIS PHARMACEUTICALS INC (US) | 1996-07-17 | — | — | EP | disclosed |
| EP-0711301-A1 | PROCESSES AND INTERMEDIATES FOR PHOSPHOROUS-CONTAINING COVALENT LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004065-A1 | PROCESSES AND INTERMEDIATES FOR PHOSPHOROUS-CONTAINING COVALENT LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1995-02-09 | — | — | WO | disclosed |
| WO-1992013869-A1 | METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM | GILEAD SCIENCES, INC. (US) | 1992-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10669301-B2 | Phosphoramidite building blocks for sugar-conjugated oligonucleotides | DERA, FBP1, PNKP | TYMP 4/4885TAAR1 4635/4885HPGD 3176/4885 |
| US-20230242569-A1 | PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | PPIP5K2, INPP5B, PTMS | TYMP 201/4885TAAR1 4417/4885HPGD 2640/4885 |
| US-20040082774-A1 | Novel phosphate and thiophosphate protecting groups | TYMP, MTAP, PPIP5K2 | TYMP 1/4885TAAR1 4605/4885HPGD 3873/4885 |
| US-11548910-B2 | Oligonucleotide production method | RNGTT, OSGEP, PHAX | TYMP 18/4885TAAR1 4419/4885HPGD 2539/4885 |
| US-11613554-B2 | Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds | PPIP5K2, INPP5B, PTMS | TYMP 201/4885TAAR1 4417/4885HPGD 2640/4885 |
| US-20190169223-A1 | OLIGONUCLEOTIDE PRODUCTION METHOD | RNGTT, OSGEP, PHAX | TYMP 18/4885TAAR1 4419/4885HPGD 2539/4885 |
| US-20190322694-A1 | NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS | PPIP5K2, INPP5B, PTMS | TYMP 143/4885TAAR1 4383/4885HPGD 2880/4885 |
| US-20230212204-A1 | REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS | PNKP, POLL, RNGTT | TYMP 53/4885TAAR1 3671/4885HPGD 4470/4885 |
| US-20030232980-A1 | Methods of producing phosphitylated compounds | PHOSPHO1, INPPL1, PLCG1 | TYMP 678/4885TAAR1 1509/4885HPGD 4700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.