SCHEMBL6835391

SCHEMBL6835391

CC1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)C(O)CC(=O)O)[C@@]2(C)C=CC(=O)C=C12

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.72
HIF1A Q16665 6/20 0.72
NR3C1 P04150 6/20 0.72
PGR P06401 6/20 0.72
HSD17B10 Q99714 4/20 0.72
ABCB11 O95342 3/20 0.72
ALDH1A1 P00352 2/20 0.72
NR1I2 O75469 2/20 0.72
ABCC4 O15439 1/20 0.72
PDE4D Q08499 1/20 0.72
AR P10275 3/20 0.67
F2 P00734 1/20 0.67
TNF P01375 1/20 0.51
IL6 P05231 1/20 0.51
SERPINA6 P08185 1/20 0.51
NR3C2 P08235 1/20 0.51
GLUL P15104 1/20 0.51
ADAM17 P78536 1/20 0.51
GPBAR1 Q8TDU6 1/20 0.51
CYP2C19 P33261 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9602408 1.00 CYP3A4 (0.72) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL2482647 0.91 CYP3A4 (0.69) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL9602646 0.91 PGR (0.59) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL21145516 0.90 CYP3A4 (0.78) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL10798820 0.88 CYP3A4 (0.74) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL10798815 0.88 CYP3A4 (0.74) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL9789817 0.88 NR3C1 (0.69) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL3406698 0.86 CYP3A4 (0.81) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL3406702 0.86 CYP3A4 (0.81) CYP3A4HIF1ANR3C1PGRHSD17B10
SCHEMBL10944298 0.86 HIF1A (0.70) CYP3A4HIF1ANR3C1PGRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230330084-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS CORCEPT THERAPEUTICS, INC. (US) 2023-10-19 US disclosed
US-11648245-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators CORCEPT THERAPEUTICS, INC. (US) 2023-05-16 US disclosed
US-11576907-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators CORCEPT THERAPEUTICS, INC. (US) 2023-02-14 US disclosed
EP-4119561-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS Corcept Therapeutics Incorporated (US) 2023-01-18 EP disclosed
US-20210369701-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS CORCEPT THERAPEUTICS, INC. 2021-12-02 US disclosed
EP-3851107-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS Corcept Therapeutics Incorporated (US) 2021-07-21 EP disclosed
US-20210169872-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS CORCEPT THERAPEUTICS, INC. 2021-06-10 US disclosed
US-10973813-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators CORCEPT THERAPEUTICS, INC. (US) 2021-04-13 US disclosed
EP-3590517-B1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS CORCEPT THERAPEUTICS INC (US) 2021-03-17 EP disclosed
US-10456392-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators CORCEPT THERAPEUTICS, INC. (US) 2019-10-29 US disclosed
US-20140038926-A1 Heteroaryl-Ketone Fused Azadecalin Glucocorticoid Receptor Modulators CORCEPT THERAPEUTICS, INC. (US) 2014-02-06 US disclosed
WO-2013177559-A2 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS CORCEPT THERAPEUTICS, INC. (US) 2013-11-28 WO disclosed
EP-2661175-A1 COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY Corcept Therapeutics, Inc. (US) 2013-11-13 EP disclosed
CN-103298343-A Combination steroid and glucocorticoid receptor antagonist therapy CORCEPT THERAPEUTICS INC 2013-09-11 CN disclosed
US-20130012486-A1 COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY Corcept Therapeutics, Inc. (019904) (US) 2013-01-10 US disclosed
WO-2012094618-A1 COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY CORCEPT THERAPEUTICS, INC. (US) 2012-07-12 WO disclosed
US-20040006240-A1 Process to prepare 11beta,17alpha ,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate PHARMACIA & UPJOHN COMPANY 2004-01-08 US disclosed
EP-0301966-B1 PHARMACEUTICAL COMPOSITIONS FOR TREATING DEGENERATIVE JOINT DISEASE Trager, Seymour F. (US) 1992-12-02 EP disclosed
US-4828828-A ANTIARTHRITIC TRAGER SEYMOUR F (US) 1989-05-09 US disclosed
EP-0301966-A2 Pharmaceutical compositions for treating degenerative joint disease Trager, Seymour F. (US) 1989-02-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210169872-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS NR3C1, NR3C2, NR5A1 CYP3A4 374/4885HIF1A 4646/4885NR3C1 1/4885
US-11648245-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators NR3C1, GRIN3A, NR3C2 CYP3A4 1984/4885HIF1A 4622/4885NR3C1 1/4885
US-20210369701-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS NR3C1, GRIN3A, NR3C2 CYP3A4 1984/4885HIF1A 4622/4885NR3C1 1/4885
US-10973813-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators NR3C1, NR3C2, NR5A1 CYP3A4 374/4885HIF1A 4646/4885NR3C1 1/4885
US-11576907-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators NR3C1, NR3C2, NR5A1 CYP3A4 374/4885HIF1A 4646/4885NR3C1 1/4885
US-20140038926-A1 Heteroaryl-Ketone Fused Azadecalin Glucocorticoid Receptor Modulators NR3C1, NR3C2, NR5A1 CYP3A4 374/4885HIF1A 4646/4885NR3C1 1/4885
US-10456392-B2 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators NR3C1, NR3C2, NR5A1 CYP3A4 374/4885HIF1A 4646/4885NR3C1 1/4885
US-20130012486-A1 COMBINATION STEROID AND GLUCOCORTICOID RECEPTOR ANTAGONIST THERAPY NR3C1, NR3C2, NR5A1 CYP3A4 3413/4885HIF1A 1062/4885NR3C1 1/4885
US-20040006240-A1 Process to prepare 11beta,17alpha ,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate CYP17A1, CYP51A1, HSD17B11 CYP3A4 96/4885HIF1A 548/4885NR3C1 117/4885
US-20230330084-A1 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS NR3C1, GRIN3A, NR3C2 CYP3A4 1984/4885HIF1A 4622/4885NR3C1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.