SCHEMBL6835459

SCHEMBL6835459

CC(=O)OCC(COC(C)=O)NC(=O)c1c(I)c(NC(=O)C(C)OC(C)=O)c(I)c(C(=O)NC(COC(C)=O)COC(C)=O)c1I

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.53
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12845762 1.00 LMNA (0.53) LMNATDP1
SCHEMBL6835457 1.00 LMNA (0.53) LMNATDP1
SCHEMBL7050768 0.88 LMNA (0.70) LMNA
SCHEMBL14334595 0.88 LMNA (0.70) LMNA
SCHEMBL16976211 0.88 LMNA (0.70) LMNA
SCHEMBL7764898 0.83 LMNA (0.64) LMNA
SCHEMBL8741593 0.83 LMNA (0.49) LMNA
SCHEMBL8978138 0.82 LMNA (0.62) LMNA
SCHEMBL9260881 0.82 LMNA (0.62) LMNA
SCHEMBL20468079 0.81 LMNA (0.60) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2975021-B1 PROCESS FOR THE PREPARATION OF IOPAMIDOL BRACCO IMAGING SPA (IT) 2017-07-26 EP disclosed
EP-1353899-B1 A PROCESS FOR THE PREPARATION OF IOPAMIDOL BRACCO IMAGING SPA (IT) 2016-01-20 EP disclosed
EP-2975021-A1 PROCESS FOR THE PREPARATION OF IOPAMIDOL Bracco Imaging SPA (IT) 2016-01-20 EP disclosed
US-20040082812-A1 Process for the preparation of iopamidol and the new intermediated therein BRACCO IMAGING S.P.A. (IT) 2004-04-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040082812-A1 Process for the preparation of iopamidol and the new intermediated therein INSR, ACVRL1, CBR3 LMNA 1132/4885TDP1 3547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.