SCHEMBL7764898

SCHEMBL7764898

CC(=O)OC(C)C(=O)Nc1c(I)c(C(N)=O)c(I)c(C(=O)NC(CO)CO)c1I

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.64
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14334595 0.95 LMNA (0.70) LMNASMN1; SMN2
SCHEMBL7050768 0.95 LMNA (0.70) LMNASMN1; SMN2
SCHEMBL9260881 0.90 LMNA (0.62) LMNA
SCHEMBL8978138 0.90 LMNA (0.62) LMNA
SCHEMBL20468079 0.88 LMNA (0.60) LMNASMN1; SMN2
SCHEMBL8586708 0.88 LMNA (0.43) LMNASMN1; SMN2
SCHEMBL23633775 0.84 LMNA (0.59) LMNASMN1; SMN2
SCHEMBL7709204 0.84 LMNA (0.90) LMNASMN1; SMN2
SCHEMBL21191482 0.84 LMNA (0.54) LMNA
SCHEMBL6835459 0.83 LMNA (0.53) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1112247-A1 A PROCESS FOR THE PREPARATION OF S-N,N'-BIS 2-HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- (2-HYDROXY-1- OXOPROPYL) AMINO]-2,4,6- TRIIODO-1,3- BENZENEDICARBOXAMIDE BRACCO IMAGING S.p.A. (IT) 2001-07-04 EP claimed
WO-2000015602-A1 A PROCESS FOR THE PREPARATION OF S-N,N'-BIS [2-HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2-HYDROXY-1- OXOPROPYL) AMINO]-2,4,6- TRIIODO-1,3- BENZENEDICARBOXAMIDE BRACCO IMAGING S.P.A. (IT) 2000-03-23 WO claimed
US-5817861-A Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media BRACCO INTERNATIONAL BV (NL) 1998-10-06 US claimed
US-5817861-A Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media BRACCO INTERNATIONAL BV (NL) 1998-10-06 US disclosed
US-5817861-A Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media BRACCO INTERNATIONAL BV (NL) 1998-10-06 US disclosed