SCHEMBL6837624

SCHEMBL6837624

FC(F)(F)c1nc2ccccc2c2c1nc(-c1ccccc1)n2CCC1CCN(Cc2ccccc2)CC1

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ACHE P22303 14/20 0.47
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
NTSR1 P30989 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ACP1 P24666 1/20 0.42
BCHE P06276 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7489095 0.85 TRPV1 (0.38)
SCHEMBL6833713 0.84 NPY1R (0.39) ACP1
SCHEMBL6838066 0.83 BRD4 (0.43) ACP1
SCHEMBL6837749 0.82 PTGER4 (0.34) LMNA
SCHEMBL6840139 0.82 ACP1 (0.38) ACP1
SCHEMBL6840074 0.80 ACP1 (0.44) ACP1
SCHEMBL6833883 0.80 KDM4E (0.42) LMNAMAPT
SCHEMBL6840049 0.79 ALDH1A1 (0.38) KMT2ANPSR1ACP1
SCHEMBL6838577 0.79 PDE6D (0.37) KMT2AACP1BCHE
SCHEMBL6833751 0.79 ACP1 (0.38) KMT2AACP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040054182-A1 1h-imidazopyridine derivatives HOKURIKU SEIYAKU CO., LTD. (JP) 2004-03-18 US disclosed
EP-1256582-A1 1H-IMIDAZOPYRIDINE DERIVATIVES HOKURIKU SEIYAKU CO., LTD. (JP) 2002-11-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040054182-A1 1h-imidazopyridine derivatives IL2, IL1A, IL4 ACHE 3705/4885LMNA 4507/4885MAPT 4595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.