Sugi Predict

Sugi Predict / Compounds / SCHEMBL6840382

SCHEMBL6840382

SCHEMBL6840382

O=C(O)c1ccc(Oc2ccc(Cl)cn2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LIPE Q05469 1/20 0.56
▸ DGAT1 O75907 1/20 0.54
▸ SOAT1 P35610 1/20 0.54
▸ KCNH2 Q12809 1/20 0.54
▸ MEN1 O00255 1/20 0.51
▸ NPC1 O15118 1/20 0.51
▸ CASP3 P42574 1/20 0.51
▸ RAB9A P51151 1/20 0.51
▸ KMT2A Q03164 1/20 0.51
▸ SENP8 Q96LD8 1/20 0.51
▸ SENP7 Q9BQF6 1/20 0.51
▸ SENP6 Q9GZR1 1/20 0.51
▸ HRH3 Q9Y5N1 2/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ NR4A2 P43354 1/20 0.50
▸ LTA4H P09960 1/20 0.49
▸ P2RX3 P56373 4/20 0.47
▸ PPARG P37231 1/20 0.47
▸ LOXL2 Q9Y4K0 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7921418 0.90 HRH3 (0.56) LIPEDGAT1SOAT1KCNH2MEN1
SCHEMBL20836099 0.87 LIPE (0.53) LIPEDGAT1SOAT1KCNH2MEN1
SCHEMBL17487332 0.86 LIPE (0.55) LIPEKCNH2MEN1NPC1CASP3
SCHEMBL20836079 0.83 LMNA (0.65) LIPEKCNH2MEN1NPC1CASP3
SCHEMBL21525644 0.82 CA1 (0.48) DGAT1SOAT1KCNH2NR4A2LOXL2
SCHEMBL1168418 0.82 PPARG (0.62) LIPEMEN1NPC1RAB9AKMT2A
SCHEMBL21525575 0.81 CA1 (0.59) NPC1RAB9ALOXL2PARP15PARP10
SCHEMBL6119765 0.81 TPMT (0.50) DGAT1SOAT1KCNH2LOXL2PARP15
SCHEMBL6840298 0.81 RXRA (0.50) DGAT1SOAT1KCNH2LOXL2PARP15
SCHEMBL4322897 0.81 KDM4E (0.53) DGAT1SOAT1MEN1KMT2AHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4628163-A1 NOVEL HETEROARYL AMINOPROPANOL DERIVATIVES Novartis AG (CH) 2025-10-08 — — EP disclosed
EP-4323062-B1 HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H NOVARTIS AG (CH) 2025-07-23 — — EP disclosed
US-20240199593-A1 Novel Heteroaryl Aminopropanol Derivatives NOVARTIS PHARMA AG (CH) 2024-06-20 — — US disclosed
US-11932630-B2 Heteroaryl aminopropanol derivatives NOVARTIS AG (CH) 2024-03-19 — — US disclosed
EP-4323062-A1 HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H Novartis AG (CH) 2024-02-21 — — EP disclosed
CN-117015537-A Heteroaryl aminopropanol derivatives as inhibitors of LTA4H 诺华股份有限公司 2023-11-07 — — CN disclosed
EP-3708165-B1 CRYSTAL FORM I OF A 5-AMINOPYRAZOLE CARBOXAMIDE COMPOUND AS BTK INHIBITOR SINOMAB BIOSCIENCE LTD (CN) 2023-01-18 — — EP disclosed
US-20220348566-A1 Novel Heteroaryl Aminopropanol Derivatives NOVARTIS AG (CH) 2022-11-03 — — US disclosed
WO-2022219546-A1 HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H NOVARTIS AG (CH) 2022-10-20 — — WO disclosed
EP-3459940-B1 5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF SUZHOU SINOVENT PHARMACEUTICALS CO LTD (CN) 2022-07-20 — — EP disclosed
US-20100324014-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-12-23 — — US disclosed
WO-2010124082-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2010124116-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2010124086-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2010124112-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2010124102-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2010124114-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2010124119-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2010124108-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 — — WO disclosed
WO-2000048993-A1 ARYLAMINOALKYLAMIDES NOVARTIS AG (CH) 2000-08-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220348566-A1 Novel Heteroaryl Aminopropanol Derivatives CYP11B2, CYP11B1, CYP3A43 LIPE 2984/4885DGAT1 1522/4885SOAT1 551/4885
US-20240199593-A1 Novel Heteroaryl Aminopropanol Derivatives CYP3A43, CYP3A5, CYP51A1 LIPE 3964/4885DGAT1 3434/4885SOAT1 2246/4885
US-11932630-B2 Heteroaryl aminopropanol derivatives CYP3A43, CYP11B2, ADRB3 LIPE 2789/4885DGAT1 1817/4885SOAT1 572/4885
US-20100324014-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS PNLIP, LPL, LIPA LIPE 6/4885DGAT1 13/4885SOAT1 199/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.