SCHEMBL68421

SCHEMBL68421

Cc1cccnc1NCCOc1ccc(CC2SC(=O)NC2=O)cc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARG P37231 12/20 0.56
FFAR1 O14842 7/20 0.54
RXRA P19793 2/20 0.51
CYP3A4 P08684 2/20 0.51
RARG P13631 1/20 0.51
PPARA Q07869 2/20 0.50
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
TP53 P04637 1/20 0.49
CYP1A2 P05177 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
ALOX15 P16050 1/20 0.49
TSHR P16473 1/20 0.49
KMT2A Q03164 1/20 0.49
HSD17B10 Q99714 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
HRH3 Q9Y5N1 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6931933 0.89 PPARG (0.56) PPARGFFAR1RXRACYP3A4RARG
SCHEMBL1848812 0.85 PPARG (0.60) PPARGFFAR1RXRACYP3A4RARG
SCHEMBL5810603 0.83 PPARG (0.61) PPARGFFAR1RXRACYP3A4RARG
SCHEMBL3117517 0.82 PPARG (0.62) PPARGFFAR1RXRACYP3A4RARG
SCHEMBL2694121 0.81 RAB9A (0.38) PPARGFFAR1RXRARARGMEN1
SCHEMBL3240600 0.80 FFAR1 (0.52) PPARGFFAR1RXRACYP3A4PPARA
SCHEMBL5883336 0.80 PPARG (0.52) PPARGFFAR1RXRACYP3A4PPARA
SCHEMBL2883389 0.79 PPARG (0.56) PPARGFFAR1RXRACYP3A4PPARA
SCHEMBL3900454 0.79 FFAR1 (0.62) PPARGFFAR1RXRACYP3A4PPARA
SCHEMBL6187999 0.79 FFAR1 (0.55) PPARGFFAR1PPARAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1041977-B1 USE OF PPAR-GAMMA ACTIVATORS FOR TREATING DERMATOLOGICAL DISORDERS GALDERMA RES & DEV (FR) 2008-07-30 EP claimed
EP-3548023-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D Therapeutics, Inc. (US) 2019-10-09 EP disclosed
WO-2018102399-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 WO disclosed
US-20180153860-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
WO-2018102358-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE T3D THERAPEUTICS, INC. (US) 2018-06-07 WO disclosed
US-20180153859-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE T3D THERAPEUTICS, INC. (US) 2018-06-07 US disclosed
EP-2788384-B1 AGONISTIC HUMAN LCAT ANTIGEN BINDING PROTEINS AND THEIR USE IN THERAPY AMGEN INC (US) 2017-08-09 EP disclosed
EP-2522721-B1 Modified lecithin-cholesterol acyltransferase enzymes AMGEN INC (US) 2016-05-04 EP disclosed
EP-2489730-B1 Modified lecithin-cholesterol acyltransferase enzymes AMGEN INC (US) 2015-12-30 EP disclosed
US-20150284471-A1 Human LCAT Antigen Binding Proteins and Their Use in Therapy AMGEN INC. 2015-10-08 US disclosed
WO-2004113331-A1 NOVEL COMPOUNDS THAT MODULATE PPARϜ TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2004-12-29 WO disclosed
WO-2004072022-A1 COMPOUNDS WHICH ARE MODULATORS OF THE PPAR-TYPE RECEPTORS AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS GALDERMA RESEARCH & DEVELOPMENT, SNC (FR) 2004-08-26 WO disclosed
WO-2004071504-A1 COMPOUNDS WHICH ARE MODULATORS OF THE PPAR-TYPE RECEPTORS AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2004-08-26 WO disclosed
WO-2004048351-A2 BIPHENYL COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2004-06-10 WO disclosed
WO-2004046091-A2 BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2004-06-03 WO disclosed
WO-2004004774-A2 COMPOSITIONS COMPRISING PANTHETINE FOR THE TREATMENT OF DYSLIPIDEMIA ESPERION THERAPEUTICS, INC. (US) 2004-01-15 WO disclosed
US-20030134885-A1 Biaromatic ligand activators of PPARgamma receptors GALDERMA RESEARCH & DEVELOPMENT (FR) 2003-07-17 US disclosed
US-6511670-B1 Compounds with shorter alkyl chains such as 3,8-dithia-5-docosynoic acid; treating acne and inflammation disorders; peroxisome proliferator activated receptor activators SOCIETE L'OREAL S.A. (FR) 2003-01-28 US disclosed
US-6403656-B1 SKIN DISORDERS GALDERMA RESEARCH & DEVELOPMENT S.N.C (FR) 2002-06-11 US disclosed
US-20020049249-A1 PPAR receptor activator compounds for treating cutaneous disorders/afflictions SOCIETE L'OREAL, S.A. (FR) 2002-04-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180153859-A1 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE CHRNA2, ACACA, CHAT PPARG 988/4885FFAR1 224/4885RXRA 2018/4885
US-20180153860-A1 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES CHAT, ACHE, CHRNA2 PPARG 621/4885FFAR1 452/4885RXRA 1199/4885
US-20030134885-A1 Biaromatic ligand activators of PPARgamma receptors PPARG, PPARA, PPARD PPARG 1/4885FFAR1 10/4885RXRA 4/4885
US-20020049249-A1 PPAR receptor activator compounds for treating cutaneous disorders/afflictions PPARG, PPARA, PPARD PPARG 1/4885FFAR1 13/4885RXRA 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.