Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018926 | 0.89 | RAB9A (0.49) | TSHRCA1CA2CA9MEN1 | |
| SCHEMBL30100506 | 0.86 | KMT2A (0.51) | TSHRCA1CA2CA9MEN1 | |
| SCHEMBL13240457 | 0.86 | ALDH1A1 (0.49) | TSHRCA1CA2CA9MEN1 | |
| SCHEMBL13240460 | 0.86 | KMT2A (0.49) | TSHRMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1114464 | 0.86 | TSHR (0.54) | TSHRCA1CA2CA9MEN1 | |
| SCHEMBL11824132 | 0.84 | MAPT (0.55) | TSHRMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL26103989 | 0.84 | CTSD (0.55) | TSHRCA1CA2SMN1; SMN2MAPT | |
| SCHEMBL6381741 | 0.83 | MAPT (0.57) | TSHRMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL11816534 | 0.83 | MAPT (0.60) | TSHRMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2181344 | 0.82 | MAPK1 (0.50) | TSHRCA1CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754773-B2 | Composition and synthesis of new reagents for inhibition of HIV replication | UNIVERSITY OF MASSACHUSETTS (US) | 2010-07-13 | — | — | US | disclosed |
| US-20070099919-A1 | Composition and synthesis of new reagents for inhibition of HIV replication | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
| US-20040030093-A1 | Metal catalyst for ring-opening polymerization of heterocyclic compound | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 2004-02-12 | — | — | US | disclosed |
| EP-1340780-A1 | METAL CATALYST FOR RING-OPENING POLYMERIZATION OF HETEROCYCLIC COMPOUND | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0706419-B1 | INTERFACIAL POLYMERIZATION IN A POROUS SUBSTRATE AND SUBSTRATES FUNCTIONALIZED WITH PHOTOCHEMICAL GROUPS | MINNESOTA MINING & MFG (US) | 2002-11-13 | — | — | EP | disclosed |
| US-5627217-A | NONBLOCKING COATING ON FIBERS; MICROFILTRATION; BIOCHEMICAL REACTIONS; SEPARATIONS; ANTIFOULING AGENTS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0597540-B1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0706419-A1 | INTERFACIAL POLYMERIZATION IN A POROUS SUBSTRATE AND SUBSTRATES FUNCTIONALIZED WITH PHOTOCHEMICAL GROUPS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001219-A1 | INTERFACIAL POLYMERIZATION IN A POROUS SUBSTRATE AND SUBSTRATES FUNCTIONALIZED WITH PHOTOCHEMICAL GROUPS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-01-12 | — | — | WO | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0597540-A1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1994-05-18 | — | — | EP | disclosed |
| US-4171976-A | Homopolymerization inhibition of photographic hardeners | EASTMAN KODAK COMPANY (US) | 1979-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040030093-A1 | Metal catalyst for ring-opening polymerization of heterocyclic compound | MAX, PCNA, POLM | TSHR 4013/4885CA1 737/4885CA2 914/4885 |
| US-20070099919-A1 | Composition and synthesis of new reagents for inhibition of HIV replication | REV1, MAVS, ISG15 | TSHR 4711/4885CA1 4741/4885CA2 4843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.