SCHEMBL684231

SCHEMBL684231

O=C(N/N=C/c1cccc(Cl)c1O)c1ccc(Cl)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.76
MEN1 O00255 5/20 0.76
KMT2A Q03164 5/20 0.76
KDM4E B2RXH2 4/20 0.76
HTT P42858 4/20 0.76
LMNA P02545 3/20 0.76
NPC1 O15118 7/20 0.63
MAPT P10636 3/20 0.63
SIRT1 Q96EB6 1/20 0.61
L3MBTL1 Q9Y468 2/20 0.60
CD38 P28907 1/20 0.59
KDM1A O60341 3/20 0.56
TDP1 Q9NUW8 2/20 0.56
USP2 O75604 1/20 0.56
MCOLN3 Q8TDD5 1/20 0.56
SMN1; SMN2 Q16637 4/20 0.55
MAOA P21397 1/20 0.55
MAOB P27338 1/20 0.55
HPGD P15428 1/20 0.54
PSMD14 O00487 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6571415 1.00 RAB9A (0.76) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL6571417 1.00 RAB9A (0.76) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL684230 0.90 RAB9A (0.78) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL684189 0.90 NPC1 (0.64) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL684794 0.89 RAB9A (0.69) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL10053130 0.88 RAB9A (0.60) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL684660 0.86 KDM1A (0.74) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL684234 0.85 MAPT (0.60) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL684862 0.83 KDM4E (0.79) RAB9AMEN1KMT2AKDM4EHTT
SCHEMBL684638 0.83 RAB9A (0.64) RAB9AMEN1KMT2AKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 RAB9A 3846/4885MEN1 536/4885KMT2A 1362/4885
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 RAB9A 3616/4885MEN1 508/4885KMT2A 1224/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS RAB9A 3936/4885MEN1 3435/4885KMT2A 2866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.