Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.51 |
| ▸ | POLA1 | P09884 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842635 | 0.91 | NR1H4 (0.59) | EPHX2NR1H4ALDH1A1PTGER4PTGER2 | |
| SCHEMBL6843325 | 0.89 | NR1H4 (0.51) | EPHX2NR1H4PTGER4PTGER2PPARG | |
| SCHEMBL6843206 | 0.89 | NR1H4 (0.51) | EPHX2NR1H4ALDH1A1PPARG | |
| SCHEMBL6843413 | 0.89 | NR1H4 (0.52) | EPHX2NR1H4ALDH1A1PTGER4RAB9A | |
| SCHEMBL6845318 | 0.89 | NR1H4 (0.51) | EPHX2NR1H4PTGER4PTGER2PPARG | |
| SCHEMBL6845364 | 0.88 | NR1H4 (0.50) | EPHX2NR1H4SMN1; SMN2 | |
| SCHEMBL6843010 | 0.87 | NR1H4 (0.48) | EPHX2NR1H4PTGER4PPARG | |
| SCHEMBL6844739 | 0.87 | CA2 (0.55) | EPHX2NR1H4 | |
| SCHEMBL6844731 | 0.87 | NR1H4 (0.48) | EPHX2NR1H4 | |
| SCHEMBL6842471 | 0.87 | MMP13 (0.54) | EPHX2NR1H4ALDH1A1PTGER4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | MMP9, MMP8, MMP13 | EPHX2 2569/4885NR1H4 1615/4885POLA1 864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.