Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | SELL | P14151 | 1/20 | 0.43 |
| ▸ | SELP | P16109 | 1/20 | 0.43 |
| ▸ | SELE | P16581 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842635 | 0.91 | NR1H4 (0.59) | NR1H4EPHX2KDM4EPTGER4MAPT | |
| SCHEMBL6843478 | 0.89 | EPHX2 (0.52) | NR1H4EPHX2RAB9APTGER4ALDH1A1 | |
| SCHEMBL6843206 | 0.89 | NR1H4 (0.51) | NR1H4EPHX2ALDH1A1SELLSELP | |
| SCHEMBL6845318 | 0.89 | NR1H4 (0.51) | NR1H4EPHX2PTGER4MAPTSELL | |
| SCHEMBL6843325 | 0.89 | NR1H4 (0.51) | NR1H4EPHX2PTGER4SELLSELP | |
| SCHEMBL6842471 | 0.89 | MMP13 (0.54) | NR1H4EPHX2NPC1RAB9APTGER4 | |
| SCHEMBL6845364 | 0.88 | NR1H4 (0.50) | NR1H4EPHX2HTTMAPK14SELL | |
| SCHEMBL6845405 | 0.88 | RORC (0.49) | NR1H4EPHX2ALDH1A1 | |
| SCHEMBL6844739 | 0.87 | CA2 (0.55) | NR1H4EPHX2 | |
| SCHEMBL6843010 | 0.87 | NR1H4 (0.48) | NR1H4EPHX2MAPK14PTGER4SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | MMP9, MMP8, MMP13 | NR1H4 1615/4885EPHX2 2569/4885KDM4E 1987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.