Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845268 | 0.83 | ROCK2 (0.42) | ROCK2MAPKAPK2ROCK1ACVRL1MGLL | |
| SCHEMBL988281 | 0.80 | ROCK2 (0.61) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL7872530 | 0.77 | ROCK2 (0.44) | ROCK2KDRMEN1KMT2AMAPK10 | |
| SCHEMBL3559320 | 0.72 | RAB9A (0.50) | ROCK2MAPKAPK2KDRROCK1KMT2A | |
| SCHEMBL26186620 | 0.69 | MAPK10 (0.43) | KDRMEN1KMT2AMAPK10MAPT | |
| SCHEMBL6845264 | 0.69 | RAB9A (0.51) | ROCK2KDRROCK1MEN1KMT2A | |
| SCHEMBL29137730 | 0.69 | ROCK2 (0.40) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL6845277 | 0.66 | ROCK2 (0.44) | ROCK2MAPKAPK2KDRROCK1MEN1 | |
| SCHEMBL22159079 | 0.66 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL28318549 | 0.66 | ALDH1A1 (0.52) | ROCK2KDRROCK1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |