Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202524 | 0.98 | TGFBR1 (0.34) | TSHRTGFBR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7945238 | 0.82 | TSHR (0.32) | TSHRTGFBR1ALDH1A1 | |
| SCHEMBL34095 | 0.79 | TGFBR1 (0.33) | TGFBR1ALDH1A1 | |
| SCHEMBL9651437 | 0.78 | TGFBR1 (0.32) | TGFBR1 | |
| Hydrochloric Acid SCHEMBL3866989 | 0.72 | TGFBR1 (0.34) | TSHRTGFBR1THRBALDH1A1 | |
| Hydrochloric Acid SCHEMBL4102058 | 0.72 | TSHR (0.43) | TSHR | |
| SCHEMBL9470604 | 0.71 | TGFBR1 (0.36) | TGFBR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL201995 | 0.71 | THRB (0.32) | TSHRTGFBR1THRBALDH1A1 | |
| Hydrochloric Acid SCHEMBL3334704 | 0.70 | ALDH1A1 (0.38) | TGFBR1ALDH1A1 | |
| SCHEMBL3776845 | 0.70 | TGFBR1 (0.35) | TGFBR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418189-A2 | The use of lignin graft polymers with improved biodegradeability | STOCKHAUSEN GmbH & CO. KG (DE) | 2004-05-12 | — | — | EP | disclosed |
| EP-1040145-B1 | METHOD FOR GRAFTING LIGNIN | STOCKHAUSEN CHEM FAB GMBH (DE) | 2004-04-07 | — | — | EP | disclosed |
| EP-1040145-A1 | METHOD FOR GRAFTING LIGNIN, POLYMERIZATES PRODUCED ACCORDING TO THE METHOD AND THE UTILIZATION THEREOF | STOCKHAUSEN GmbH & CO. KG (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999031155-A1 | METHOD FOR GRAFTING LIGNIN, POLYMERIZATES PRODUCED ACCORDING TO THE METHOD AND THE UTILIZATION THEREOF | STOCKHAUSEN GMBH & CO. KG (DE) | 1999-06-24 | — | — | WO | disclosed |