SCHEMBL684597

SCHEMBL684597

O=C(N/N=C/c1cc(Br)cc(Br)c1O)c1ccccc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.77
MEN1 O00255 9/20 0.77
KMT2A Q03164 9/20 0.77
KDM4E B2RXH2 5/20 0.77
LMNA P02545 5/20 0.77
HTT P42858 3/20 0.77
NPC1 O15118 3/20 0.77
SMN1; SMN2 Q16637 2/20 0.77
L3MBTL1 Q9Y468 2/20 0.77
PKM P14618 1/20 0.77
SAE1 Q9UBE0 1/20 0.77
UBA2 Q9UBT2 1/20 0.77
MAPK1 P28482 3/20 0.72
SIRT1 Q96EB6 6/20 0.67
RAB9A P51151 3/20 0.66
NPSR1 Q6W5P4 1/20 0.66
HPGD P15428 1/20 0.65
TDP1 Q9NUW8 2/20 0.63
POLB P06746 2/20 0.62
GAA P10253 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31615212 1.00 MAPT (0.77) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL31575065 0.90 MEN1 (0.79) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL683772 0.90 MEN1 (0.79) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL684889 0.90 MAPT (0.77) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL19283322 0.89 MEN1 (0.77) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL19283323 0.89 MEN1 (0.77) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL15853618 0.89 MEN1 (0.77) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL684936 0.87 SIRT1 (0.67) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL13549794 0.87 KMT2A (0.69) MAPTMEN1KMT2AKDM4ELMNA
SCHEMBL15887143 0.87 KMT2A (1.00) MAPTMEN1KMT2AKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 MAPT 1491/4885MEN1 536/4885KMT2A 1362/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS MAPT 3866/4885MEN1 3435/4885KMT2A 2866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.