SCHEMBL684636

SCHEMBL684636

Cc1ccc(C(=O)N/N=C/c2ccc(Cl)c(Cl)c2O)cc1

nearest known ligand 0.70

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.70
SIRT1 Q96EB6 2/20 0.60
RAB9A P51151 3/20 0.58
KDM4E B2RXH2 2/20 0.58
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
LMNA P02545 1/20 0.58
HTT P42858 1/20 0.58
NPC1 O15118 3/20 0.54
L3MBTL1 Q9Y468 3/20 0.54
GAA P10253 1/20 0.52
PIK3CG P48736 1/20 0.48
USP2 O75604 1/20 0.48
MCOLN3 Q8TDD5 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
KDM1A O60341 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL684638 0.89 RAB9A (0.64) MAPTSIRT1RAB9AKDM4EMEN1
SCHEMBL683963 0.88 NPC1 (0.65) MAPTSIRT1RAB9AKDM4EMEN1
SCHEMBL684203 0.86 RAB9A (0.56) MAPTRAB9AKDM4EMEN1KMT2A
SCHEMBL685009 0.85 MAPT (0.54) MAPTRAB9AKDM4EMEN1KMT2A
SCHEMBL684794 0.84 RAB9A (0.69) MAPTSIRT1RAB9AKDM4EMEN1
SCHEMBL684641 0.83 MAPT (0.58) MAPTRAB9AKDM4EMEN1KMT2A
SCHEMBL684751 0.83 PIK3CG (0.71) MAPTKDM4EMEN1KMT2ALMNA
SCHEMBL683966 0.81 MAPT (0.58) MAPTSIRT1RAB9AKDM4EMEN1
SCHEMBL684490 0.81 KMT2A (0.73) MAPTSIRT1RAB9AKDM4EMEN1
SCHEMBL685010 0.80 KDM1A (0.67) MAPTRAB9AKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 MAPT 1491/4885SIRT1 2400/4885RAB9A 3846/4885
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 MAPT 921/4885SIRT1 1977/4885RAB9A 3616/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.