SCHEMBL684751

SCHEMBL684751

Cc1ccc(C(=O)N/N=C/c2ccc(Cl)c(Cl)c2O)c(O)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 5/20 0.71
MAPT P10636 4/20 0.54
KMT2A Q03164 4/20 0.54
LMNA P02545 3/20 0.54
MEN1 O00255 3/20 0.54
HTT P42858 2/20 0.54
MAPK1 P28482 2/20 0.54
KDM4E B2RXH2 1/20 0.54
BLM P54132 1/20 0.54
PKM P14618 2/20 0.53
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
NTRK1 P04629 2/20 0.49
POLB P06746 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
CD38 P28907 1/20 0.47
GCGR P47871 1/20 0.47
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL684238 0.86 PIK3CG (0.75) PIK3CGMAPTKMT2ALMNAMEN1
SCHEMBL684718 0.84 PIK3CG (0.84) PIK3CGMAPTKMT2ALMNAMEN1
SCHEMBL683923 0.83 PIK3CG (1.00) PIK3CGMAPTKMT2ALMNAMEN1
SCHEMBL684899 0.83 PIK3CG (0.82) PIK3CGMAPTKMT2ALMNAMEN1
SCHEMBL684758 0.83 PIK3CG (0.67) PIK3CGMAPTKMT2ALMNAMEN1
SCHEMBL684636 0.83 MAPT (0.70) PIK3CGMAPTKMT2ALMNAMEN1
SCHEMBL684956 0.83 NTRK1 (0.71) MAPTKMT2ALMNAMEN1HTT
SCHEMBL685009 0.81 MAPT (0.54) MAPTKMT2ALMNAMEN1HTT
SCHEMBL685300 0.81 PIK3CG (0.83) PIK3CGMAPTKMT2ALMNAMEN1
SCHEMBL684001 0.81 PIK3CG (1.00) PIK3CGMAPTKMT2ALMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 PIK3CG 2876/4885MAPT 1491/4885KMT2A 1362/4885
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 PIK3CG 2911/4885MAPT 921/4885KMT2A 1224/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS PIK3CG 2827/4885MAPT 3866/4885KMT2A 2866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.