Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746660 | 0.80 | PPARG (0.48) | PPARGLMNAHTTMCL1TSHR | |
| SCHEMBL5747345 | 0.78 | PPARG (0.54) | PPARGLMNAHTTSMN1; SMN2MCL1 | |
| SCHEMBL5794958 | 0.77 | PPARG (0.42) | PPARGLMNAHTTSMN1; SMN2MCL1 | |
| SCHEMBL5745185 | 0.77 | LMNA (0.47) | LMNACASP3TP53 | |
| SCHEMBL5745670 | 0.75 | PPARG (0.52) | PPARGLMNAHTTSMN1; SMN2MCL1 | |
| SCHEMBL5747047 | 0.74 | PPARG (0.50) | PPARGLMNAHTTMCL1MAPK1 | |
| Hydroxyamine SCHEMBL5794953 | 0.73 | RAB9A (0.43) | PPARGLMNASMN1; SMN2MCL1TSHR | |
| SCHEMBL6841912 | 0.73 | RAB9A (0.45) | LMNAHTTSMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL5746078 | 0.73 | PPARG (0.53) | PPARGLMNAHTTSMN1; SMN2MCL1 | |
| SCHEMBL5745145 | 0.72 | PPARG (0.55) | PPARGLMNAHTTSMN1; SMN2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713477-B1 | 1,4-BENZTHIAZINES OR BENZOXAZINES; MATRIX METALLOPROTEINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-30 | — | — | US | disclosed |