SCHEMBL684960

SCHEMBL684960

O=C(N/N=C/c1cc(Cl)cc(C(F)(F)F)c1O)c1ccccc1O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.61
PTGS2 P35354 1/20 0.61
MEN1 O00255 9/20 0.57
KMT2A Q03164 9/20 0.57
KDM4E B2RXH2 5/20 0.57
MAPK1 P28482 4/20 0.57
TDP1 Q9NUW8 2/20 0.57
TP53 P04637 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
HPGD P15428 1/20 0.57
HSD17B10 Q99714 1/20 0.57
NTRK1 P04629 3/20 0.56
HTT P42858 7/20 0.56
MAPT P10636 7/20 0.56
PIK3CG P48736 1/20 0.54
LMNA P02545 3/20 0.50
BLM P54132 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
PKM P14618 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL685291 0.92 KMT2A (0.51) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL9921060 0.87 ALOX5 (0.72) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL683949 0.86 ALOX5 (0.64) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL685006 0.86 ALOX5 (0.60) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL683972 0.86 PIK3CG (0.74) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL1639165 0.84 PIK3CG (0.72) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL1639164 0.84 PIK3CG (0.72) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL683738 0.84 PIK3CG (0.72) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL685152 0.84 PIK3CG (0.59) ALOX5PTGS2MEN1KMT2AKDM4E
SCHEMBL684627 0.83 KMT2A (0.67) ALOX5PTGS2MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-20120148682-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-06-14 US disclosed
US-20120148682-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-06-14 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 ALOX5 2022/4885PTGS2 2788/4885MEN1 536/4885
US-20120148682-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 ALOX5 1904/4885PTGS2 2914/4885MEN1 508/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS ALOX5 745/4885PTGS2 127/4885MEN1 3435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.