Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.46 |
| ▸ | MMP13 | P45452 | 5/20 | 0.46 |
| ▸ | MMP8 | P22894 | 4/20 | 0.46 |
| ▸ | MMP7 | P09237 | 3/20 | 0.46 |
| ▸ | MMP12 | P39900 | 3/20 | 0.46 |
| ▸ | BMP1 | P13497 | 3/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 9/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP16 | P51512 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067174 | 0.90 | MMP1 (0.54) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL6850427 | 0.87 | BMP1 (0.43) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL6850876 | 0.84 | MMP1 (0.46) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL328418 | 0.84 | MMP1 (0.45) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL6850534 | 0.81 | MMP13 (0.40) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL6850891 | 0.79 | ALDH1A1 (0.43) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL328402 | 0.78 | MEP1B (0.44) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL328404 | 0.78 | BMP1 (0.43) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL328653 | 0.77 | MMP13 (0.46) | MMP1MMP13MMP8MMP7MMP12 | |
| SCHEMBL328410 | 0.76 | MEP1B (0.42) | MMP1MMP13MMP8MMP7MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011011181-A1 | PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | AMICUS THERAPEUTICS, INC. (US) | 2011-01-27 | — | — | WO | disclosed |