SCHEMBL68514

SCHEMBL68514

COC[C@H]1O[C@@H](n2cc(C)c(N)nc2=O)C[C@@H]1OC

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ DNMT1 P26358 3/20 0.36
▸ ADRB1 P08588 1/20 0.36
▸ RNASE1 P07998 1/20 0.36
▸ TK1 P04183 1/20 0.35
▸ ALB P02768 1/20 0.35
▸ POLG P54098 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12590058 1.00 DNMT1 (0.36) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL18573362 1.00 DNMT1 (0.36) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL24291985 0.91 DNMT1 (0.35) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL12087580 0.90 ALB (0.38) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL12015121 0.90 ALB (0.38) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL67563 0.90 ALB (0.38) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL22758328 0.89 DNMT1 (0.35) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL24517423 0.89 RNASE1 (0.46) DNMT1ADRB1RNASE1TK1ALB
SCHEMBL21227129 0.88 DNMT1 (0.40) DNMT1ADRB1ALBPOLG
SCHEMBL14555941 0.88 DNMT1 (0.38) DNMT1ADRB1ALBPOLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230193287-A1 Nucleic Acid Compounds for Binding Growth Differentiation Factor 11 SOMALOGIC OPERATING CO., INC. (US) 2023-06-22 — — US disclosed
US-20180187197-A1 Multiaptamer Target Detection SOMALOGIC OPERATING CO., INC. 2018-07-05 — — US disclosed
US-20180016581-A1 NUCLEIC ACID COMPOUNDS FOR BINDING GROWTH DIFFERENTIATION FACTOR 8 SOMALOGIC, INC. (US) 2018-01-18 — — US disclosed
US-20160348112-A1 Compositions and Methods for Detecting Microorganisms SOMALOGIC OPERATING CO. INC. 2016-12-01 — — US disclosed
US-20160324927-A1 COMPOSITIONS AND METHODS FOR IDENTIFYING, MODULATING AND MONITORING DRUG TARGETS IN MUSCULAR DISEASE SOMALOGIC, INC. 2016-11-10 — — US disclosed
US-20150031585-A1 Multiaptamer Target Detection SOMALOGIC, INC. 2015-01-29 — — US disclosed
US-8129106-B2 Sequence-specific detection of methylation in biomolecules Max-Planck-Geselischaft zur Forderung der Wissenschaften E.V. (DE) 2012-03-06 — — US disclosed
US-20110165564-A1 SEQUENCE-SPECIFIC DETECTION OF METHYLATION IN BIOMOLECULES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2011-07-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160324927-A1 COMPOSITIONS AND METHODS FOR IDENTIFYING, MODULATING AND MONITORING DRUG TARGETS IN MUSCULAR DISEASE SMN1; SMN2, MUSK, UTRN DNMT1 783/4885ADRB1 852/4885RNASE1 81/4885
US-20230193287-A1 Nucleic Acid Compounds for Binding Growth Differentiation Factor 11 MSTN, S100A11, IGF2BP1 DNMT1 1236/4885ADRB1 4051/4885RNASE1 370/4885
US-20110165564-A1 SEQUENCE-SPECIFIC DETECTION OF METHYLATION IN BIOMOLECULES DNMT1, MAT2B, AHCY DNMT1 1/4885ADRB1 3648/4885RNASE1 726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback