Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | RARA | P10276 | 2/20 | 0.35 |
| ▸ | RARB | P10826 | 2/20 | 0.35 |
| ▸ | RARG | P13631 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3103198 | 0.87 | KDM4E (0.43) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 | |
| SCHEMBL5475249 | 0.86 | KDM4E (0.53) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 | |
| SCHEMBL3123352 | 0.78 | KDM4E (0.43) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 | |
| SCHEMBL2747082 | 0.77 | KDM4E (0.47) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 | |
| SCHEMBL28197969 | 0.75 | LMNA (0.47) | KDM4EALDH1A1P2RX7MAPTHPGD | |
| SCHEMBL15093129 | 0.75 | ALDH1A1 (0.43) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 | |
| SCHEMBL4412220 | 0.75 | GRIN2D (0.50) | ALDH1A1EPHX2MAPTMEN1KMT2A | |
| SCHEMBL5834020 | 0.73 | KDM4E (0.51) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 | |
| SCHEMBL4309684 | 0.73 | KDM4E (0.46) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 | |
| SCHEMBL3823755 | 0.72 | KDM4E (0.43) | KDM4EHIF1AEPAS1ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367046-A9 | Disubstituted lavendustin A analogs and pharmaceutical compositions comprising the analogs | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2004-05-12 | — | — | EP | disclosed |
| EP-1367046-A1 | Disubstituted lavendustin A analogs and pharmaceutical compositions comprising the analogs | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-1060160-A2 | DISUBSTITUTED LAVENDUSTIN A ANALOGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ANALOGS | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999043636-A2 | DISUBSTITUTED LAVENDUSTIN A ANALOGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE ANALOGS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THESECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-09-02 | — | — | WO | disclosed |