Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855523 | 0.92 | TSHR (0.39) | NOTUMADRB3TMEM97HRH3GAA | |
| SCHEMBL6854963 | 0.90 | NOTUM (0.40) | NOTUMADRB3TMEM97HRH3GAA | |
| SCHEMBL24842047 | 0.89 | ADRB3 (0.40) | NOTUMADRB3TMEM97HRH3HTT | |
| SCHEMBL6855922 | 0.87 | TBXAS1 (0.37) | NOTUMALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL31728124 | 0.85 | NOTUM (0.43) | NOTUMADRB3TMEM97HRH3GAA | |
| SCHEMBL23588215 | 0.81 | NOTUM (0.40) | NOTUMADRB3TMEM97HRH3ALDH1A1 | |
| SCHEMBL15199612 | 0.80 | ADRB3 (0.44) | NOTUMADRB3TMEM97HRH3TP53 | |
| SCHEMBL4784720 | 0.80 | NOTUM (0.46) | NOTUMADRB3TMEM97HRH3HTT | |
| SCHEMBL6858064 | 0.80 | TBXAS1 (0.39) | HRH3TSHRHSD17B10TDP1LMNA | |
| SCHEMBL6849821 | 0.78 | LMNA (0.40) | ALDH1A1SMN1; SMN2JMJD6CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831177-B1 | Preparation of their intermediates, 2-acyl-5-benzylfuran derivatives and 1,2,4-triazole-3- carboxylic acid ester derivatives | SHIONOGI & CO., LTD. (JP) | 2004-12-14 | — | — | US | disclosed |
| EP-1186599-A1 | NOVEL PROCESSES FOR THE PREPARATION OF SUBSTITUTED PROPENONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2002-03-13 | — | — | EP | disclosed |