Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855118 | 0.83 | HRH3 (0.42) | SMN1; SMN2PARP1PARP2CYP1A2ACHE | |
| SCHEMBL4131464 | 0.78 | ACHE (0.40) | PARP1SIGMAR1ACHEDRD2HRH3 | |
| SCHEMBL6858212 | 0.77 | ACHE (0.38) | KEAP1SMN1; SMN2PARP1PARP2POLB | |
| SCHEMBL6853955 | 0.76 | DRD2 (0.42) | PARP1SIGMAR1ACHEDRD2HRH3 | |
| SCHEMBL6855141 | 0.72 | KMT2A (0.42) | SMN1; SMN2POLBKMT2AALDH1A1 | |
| SCHEMBL1998867 | 0.72 | KEAP1 (0.71) | KEAP1SMN1; SMN2CYP1A2POLBUSP2 | |
| SCHEMBL1029528 | 0.70 | ADRA1B (0.48) | KEAP1SMN1; SMN2KMT2AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL9400430 | 0.70 | KEAP1 (0.68) | KEAP1SMN1; SMN2CYP1A2POLBUSP2 | |
| SCHEMBL11222517 | 0.70 | KEAP1 (0.68) | KEAP1SMN1; SMN2CYP1A2POLBUSP2 | |
| SCHEMBL7239607 | 0.67 | KEAP1 (0.71) | KEAP1SMN1; SMN2CYP1A2POLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784293-B1 | SOLUTION AND SOLID-PHASE SYNTHESIS OF BOC-PROTECTED 3-AMINOHYDANTOINS/THIOHYDANTOINS AND 3-AMINODIHYDROURACILS/ DIHYDROTHIOURACILS | THE PROCTER & GAMBLE COMPANY | 2004-08-31 | — | — | US | disclosed |