Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.67 |
| ▸ | CTSK | P43235 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011360 | 0.81 | CTSK (1.00) | CTSLCTSKALDH1A1CTSBUSP30 | |
| SCHEMBL6858424 | 0.81 | CTSL (0.65) | CTSLCTSKSMN1; SMN2HSD11B1HTT | |
| SCHEMBL6858450 | 0.74 | UCHL1 (0.50) | CTSLCTSKSMN1; SMN2HSD11B1HTT | |
| SCHEMBL6340411 | 0.68 | MMP12 (0.59) | SMN1; SMN2HSD11B1HTTCYP2C19ALDH1A1 | |
| SCHEMBL15792835 | 0.68 | HTT (0.53) | SMN1; SMN2HSD11B1HTTCYP2C19ALDH1A1 | |
| SCHEMBL15792834 | 0.68 | HTT (0.53) | SMN1; SMN2HSD11B1HTTCYP2C19ALDH1A1 | |
| SCHEMBL13482093 | 0.67 | HTT (0.46) | SMN1; SMN2HSD11B1HTTCYP2C19ALDH1A1 | |
| SCHEMBL13482095 | 0.67 | HTT (0.45) | SMN1; SMN2HSD11B1HTTCYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2314947 | 0.67 | HTT (0.45) | SMN1; SMN2HSD11B1HTTCYP2C19ALDH1A1 | |
| SCHEMBL23613809 | 0.67 | MMP12 (0.60) | SMN1; SMN2HSD11B1HTTCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6835727-B2 | Bone disorders; osteoporosis; rheumatic diseases | MERCK FROSST CANADA & CO. (CA) | 2004-12-28 | — | — | US | claimed |
| US-20030229226-A1 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA LTD. (CA) | 2003-12-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229226-A1 | Cathepsin cysteine protease inhibitors | CTSK, CTSZ, CTSE | CTSL 10/4885CTSK 1/4885SMN1; SMN2 4758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.