Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 3/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979590 | 0.76 | SIGMAR1 (0.48) | SIGMAR1RAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL4983449 | 0.76 | SIGMAR1 (0.66) | SIGMAR1KIF11GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6860362 | 0.69 | RAB9A (0.43) | KIF11RAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL27297321 | 0.68 | ITGB3 (0.37) | SIGMAR1MAPK1 | |
| Hydrochloric Acid SCHEMBL4983242 | 0.68 | RAB9A (0.42) | KIF11RAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL5450312 | 0.68 | HTR3E (0.54) | MAPK1NPSR1SLC22A2SLC22A1SLC22A3 | |
| Hydrochloric Acid SCHEMBL27328996 | 0.67 | SIGMAR1 (0.37) | SIGMAR1MAPK1 | |
| SCHEMBL6858733 | 0.65 | KIF11 (0.59) | KIF11RAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL4348957 | 0.65 | KIF11 (0.59) | KIF11RAB9ASMN1; SMN2NPC1MAPK1 | |
| SCHEMBL8397802 | 0.65 | KIF11 (0.55) | KIF11RAB9ASMN1; SMN2NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787569-B1 | INHIBITORS OF NEUROTRANSMITTER (E.G., GLUTAMATE) RELEASE FROM ISCHEMIC NEURONAL CELLS; N,N-DISUBSTITUTED GUANIDINES; NEUROLOGICAL CONDITIONS SUCH AS EPILEPSY, NEURODEGENERATIVE CONDITIONS AND/OR NERVE CELL DEATH FROM STROKE OR HEART ATTACK | CAMBRIDGE NEUROSCIENCE, INC. | 2004-09-07 | — | — | US | disclosed |
| WO-1995020950-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1995-08-10 | — | — | WO | disclosed |