Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.44 |
| ▸ | MMP1 | P03956 | 9/20 | 0.41 |
| ▸ | MMP2 | P08253 | 5/20 | 0.41 |
| ▸ | MMP9 | P14780 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.40 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.40 |
| ▸ | ADAM8 | P78325 | 2/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802607 | 0.80 | MMP2 (0.52) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL1801386 | 0.75 | ADAMTS7 (0.50) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL1801383 | 0.75 | ADAMTS7 (0.50) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL4377322 | 0.74 | ADAM17 (0.56) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL1800019 | 0.70 | MMP2 (0.62) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL4290532 | 0.70 | ADAM17 (0.50) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL8016573 | 0.70 | MMP7 (0.65) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL1796951 | 0.70 | MMP1 (0.60) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL1796948 | 0.70 | MMP1 (0.60) | MMP13MMP1MMP2MMP9MMP7 | |
| SCHEMBL8391505 | 0.70 | ALDH1A1 (0.57) | MMP1MMP2MMP9MMP7ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-A1 | HUMAN ADAM-10 INHIBITORS | Exelixis, Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003051825-A1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS, INC. (US) | 2003-06-26 | — | — | WO | disclosed |