Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | CTSC | P53634 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862266 | 0.78 | TRPV4 (0.50) | ALDH1A1MCOLN3L3MBTL1MAPK1POLB | |
| SCHEMBL6865452 | 0.75 | KMT2A (0.49) | ALDH1A1MCOLN3SMN1; SMN2TSHRPOLB | |
| SCHEMBL15040616 | 0.70 | L3MBTL1 (1.00) | L3MBTL1SMN1; SMN2TP53CASP1MAPK1 | |
| SCHEMBL16348222 | 0.70 | L3MBTL1 (0.78) | ALDH1A1MCOLN3L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL6857880 | 0.69 | L3MBTL1 (0.48) | ALDH1A1MCOLN3L3MBTL1TSHRPOLB | |
| SCHEMBL25340698 | 0.69 | L3MBTL1 (0.72) | ALDH1A1MCOLN3L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL15018230 | 0.69 | L3MBTL1 (0.59) | ALDH1A1MCOLN3L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL3526723 | 0.68 | ALDH1A1 (0.53) | ALDH1A1MCOLN3L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL16342268 | 0.68 | L3MBTL1 (0.58) | ALDH1A1MCOLN3L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL4608783 | 0.66 | PDE4A (0.88) | ALDH1A1L3MBTL1SMN1; SMN2TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |