Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862282 | 0.75 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2TSHRMCOLN3POLB | |
| SCHEMBL10743667 | 0.73 | TSHR (0.60) | KMT2APHGDHALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6862266 | 0.73 | TRPV4 (0.50) | KMT2AALDH1A1MAPTNPC1MCOLN3 | |
| SCHEMBL5528618 | 0.64 | L3MBTL1 (0.46) | KMT2AALDH1A1MAPTNPC1TSHR | |
| SCHEMBL17131916 | 0.63 | PHGDH (1.00) | KMT2APHGDHALDH1A1MAPTNPC1 | |
| SCHEMBL21062757 | 0.62 | RAB9A (0.40) | KMT2AALDH1A1MAPTNPC1LMNA | |
| SCHEMBL6857880 | 0.61 | L3MBTL1 (0.48) | KMT2AALDH1A1TSHRMCOLN3LMNA | |
| SCHEMBL3247679 | 0.61 | NPC1 (0.49) | KMT2AALDH1A1MAPTNPC1LMNA | |
| SCHEMBL7064467 | 0.60 | MAPT (0.53) | KMT2AALDH1A1MAPTNPC1TSHR | |
| SCHEMBL31124656 | 0.60 | MAPT (0.53) | KMT2AALDH1A1MAPTNPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |