Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MMP16 | P51512 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328659 | 0.91 | RORC (0.40) | RORCPOLBALDH1A1TDP1KMT2A | |
| SCHEMBL6851737 | 0.91 | TDP1 (0.41) | MMP1MMP13MMP9TDP1KMT2A | |
| SCHEMBL6850285 | 0.88 | MMP13 (0.41) | MMP1MMP13MMP9ADAM17RORC | |
| SCHEMBL6863154 | 0.83 | MMP1 (0.40) | MMP1MMP13MMP9TDP1MMP3 | |
| SCHEMBL6864863 | 0.81 | MMP2 (0.45) | MMP1MMP13MMP9ADAM17MMP3 | |
| SCHEMBL328492 | 0.81 | MMP1 (0.42) | MMP1MMP13MMP9MMP3BMP1 | |
| SCHEMBL328493 | 0.80 | TDP1 (0.44) | MMP1MMP13MMP9TDP1KMT2A | |
| SCHEMBL6863158 | 0.80 | MMP3 (0.43) | MMP1MMP13MMP9MMP3BMP1 | |
| SCHEMBL328407 | 0.80 | MMP1 (0.43) | MMP1MMP13MMP9MMP3BMP1 | |
| SCHEMBL328649 | 0.80 | MMP1 (0.44) | MMP1MMP13MMP9KMT2AMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |